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such as phosphorylation, and in a more sustained fashion, one day after the initiating event, accompanied by changes in gene expression [1–3] . Ischemic preconditioning, consisting of brief cycles of ischemia–reperfusion ...
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machinery itself and cellular structures is relatively unexplored. To help understand the role for the compartmentalization and localized protein synthesis in cell migration, we have used scanning confocal ...
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initiation through changing local PI3P levels. Double-FYVE-containing protein 1 (DFCP1) has been identiï¬ed as a downstream effector of PI3P (Axe et al. 2008). DFCP1 binds to PI3P via its FYVE domain ...
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proteins are myristylated, and myristylation is important for membrane binding and proper localization of many proteins. 20,21 However, myristylation has many other roles beyond membrane binding. For example ...
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Collagen plays a crucial role in hemostasis and thrombosis by activating platelets and reportedly induces the phosphorylation of heat shock protein (HSP) 27 in human platelets. However, the exact ...
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localized signals controlling membrane dynamics by specifically recruiting cytosolic protein effectors that mediate membrane deformation, expansion and vesicle transport ( Figure 2 B). The prototypical ...
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checkpoint of the cell cycle is a ubiquitous event in cancer that allows for inappropriate entry into the cell cycle [ 1 ]. The tumour suppressor pRB (retinoblastoma protein) has a central role ...
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vasorelaxation. cGMP melatonin MT 2 receptors protein kinase G smooth muscle relaxation phosphodiesterase 5 an increasing body of evidence supports a role for melatonin in the local regulation of vascular tone ...
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. In the framework of chromatin remodeling activities, the poly(ADP-ribosyl)ation of nuclear proteins catalyzed by PARPs, particularly PARP-1 and PARP-2, plays a fundamental role and as such have the potential ...