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, such as dendritic cells, use macropinocytosis to ingest relatively large volumes of extracellular ï¬uid and thus take up potential antigens for presentation. Binding of ligands to their cellular receptors induces ...
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by removing the receptor and its ligand from the cell surface via receptor-mediated endocytosis. In yeasts and mammals, there is strong evidence that this requires coordinated actin assembly and disassembly ...
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the plasma membrane. We found that phagosomes formed by engagement of integrins that serve as complement receptors (CR3) undergo secondary waves of actin polymerization, leading to the formation of “comet ...
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to understand the energetics, kinetics, and dynamics of cell adhesion and spreading. A thermodynamic framework for cell adhesion mediated by receptor–ligand binding was established in the pioneering work of Bell ...
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throughout the cells, whereas localized β2 -adrenergic receptor stimulation does not elicit cAMP diffusion. If the cAMP spatiotemporal dynamics depends on the source of cAMP, then the contributors ...
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by turning local signals ( Li and Bowerman, 2010 ). For instance, symmetry breaking in the macromolecular assembly of dynamic actin filaments results in asymmetric generation of the protrusive force ...
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from the lamellipodial actin network . These protrusions and retractions are promoted by a dynamic balance between actin polymerization at the barbed ends of a filament and the retrograde flow ...
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or polymeric ligand, has on surface receptors and cortical cytoskeletal components using a muscle cell culture system ( 60 ). We present evidence that laminin polymerization occurs preferentially on cell ...
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other interesting implications that are not immediately connected with the uptake of nutrients. Receptor-mediated endocytosis can be either constitutive or ligand induced. In the constitutive process ...