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for: redundant and unique regulation of activated mouse b lymphocytes by il
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Redundant and unique regulation of activated mouse B lymphocytes by IL-4 and IL-21
Jin, Haoli; Malek, Thomas R.
Follow Journal of Leukocyte Biology , Volume 80 (6): 1416
Fed of American Socs for Experimental Biology – Dec 1, 2006Redundant and unique regulation of activated mouse B lymphocytes by IL-4 and IL-21 Haoli Jin 1 and Thomas R. Malek 2 Department of Microbiology and Immunology, Miller School of Medicine, University ...
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IL-6/IL-6 receptor system and its role in physiological and pathological conditions
Masahiko Mihara, Misato Hashizume, Hiroto Yoshida, Miho Suzuki and Masashi Shiina
Follow Clinical Science , Volume 122 (4)
Portland Press – Feb 1, 2012IL (interleukin)-6, which was originally identified as a B-cell differentiation factor, is a multifunctional cytokine that regulates the immune response, haemopoiesis, the acute phase response ...
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Unique functions for protein kinase D1 and protein kinase D2 in mammalian cells
Sharon A. Matthews* 1 , Maria N. Navarro† 1 , Linda V. Sinclair†, Elizabeth Emslie†, Carmen Feijoo‑Carnero† and Doreen A. Cantrell† 2
Follow Biochemical Journal , Volume 432 (1)
Portland Press – Nov 15, 2010isoform expressed in lymphoid tissues, but that PKD2 catalytic activity is not essential for the development of mature peripheral T- and B-lymphocytes. PKD2 catalytic activity is, however, required ...
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Immunotherapy for metastatic melanoma
Zito, Christopher R.; Kluger, Harriet M.
Follow Journal of Cellular Biochemistry , Volume 113 (3)
Wiley – Jan 20, 2012cohorts.With the initial activity of IL‐2 in the treatment of advanced melanoma, other interleukins, such as interleukin‐21 (IL‐21), have been studied in early phase clinical trials. IL‐21 regulates B ...
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Mouse CD8α+ DCs and human BDCA3+ DCs are major producers of IFN-λ in response to poly IC
Lauterbach, Henning; Bathke, Barbara; Gilles, Stefanie; Traidl-Hoffmann, Claudia; Luber, Christian A.; Fejer, György; Freudenberg, Marina A.; Davey, Gayle M.; Vremec, David; Kallies, Axel; Wu, Li; Shortman, Ken; Chaplin, Paul; Suter, Mark; O’Keeffe, Meredith; Hochrein, Hubertus
Follow The Journal of Experimental Medicine , Volume 207 (12): 2703
Rockefeller University Press – Nov 22, 2010) and shown to be related to type I IFNs (IFN-Is) and the IL-10 family of cytokines. IFN-λs signal via a heterodimeric receptor, consisting of one chain unique for IFN-λ (IFN-λR1 or IL-28Rα) and another chain ...
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Casein kinase 1ॅ governs antigen-receptor-induced NF-॔B activation and human lymphoma cell survival
Bidère, Nicolas; Ngo, Vu N.; Lee, Jeansun; Collins, Cailin; Zheng, Lixin; Wan, Fengyi; Davis, R. Eric; Lenz, Georg; Anderson, D. Eric; Arnoult, Damien; Vazquez, Aimé; Sakai, Keiko; Zhang, Jun; Meng, Zhaojing; Veenstra, Timothy D.; Staudt, Louis M.; Lenardo, Michael J.
Follow Nature , Volume 458 (7234)
Nature Publishing Group (NPG) – Dec 31, 2008when levels of CK1ै or CK1ϵ were reduced ( Supplementary Fig. 6 ). Thus, among the CK1s, CK1ॅ provides an essential, non-redundant function in regulating TCR-induced NF-॔B activation.To achieve ...
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Autoimmune and inflammatory mechanisms of CNS damage
Kapadia, Minesh; Sakic, Boris
Follow Progress in Neurobiology , Volume 95 (3)
Elsevier – Nov 1, 2011activation, and cortical neuronal damage ( Aloisi and Pujol-Borrell, 2006; Magliozzi et al., 2007, 2010; Serafini et al., 2004 ). Interestingly, a substantial proportion of the brain-infiltrating B lymphocytes ...
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Differential antitumor effect of interleukin‐12 family cytokines on orthotopic hepatocellular carcinoma
Lo, Chia‐Hui; Chang, Chia‐Ming; Tang, Shih‐Wen; Pan, Wen‐Yu; Fang, Cheng‐Chieh; Chen, Yin; Wu, Ping‐Yi; Chen, Kai‐Yun; Ma, Hsin‐I; Xiao, Xiao; Tao, Mi‐Hua
Follow Journal of Gene Medicine , Volume 12 (5)
Wiley – May 1, 2010, but not redundant, roles in regulating lymphocyte subpopulations. IL‐12 is known as a potent antitumor cytokine, whereas the results of the antitumor effect of IL‐23 and IL‐27 are inconsistent. The present study ...
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T cell suppression by osteoclasts in vitro
Grassi, Francesco; Manferdini, Cristina; Cattini, Luca; Piacentini, Anna; Gabusi, Elena; Facchini, Andrea; Lisignoli, Gina
Follow Journal of Cellular Physiology , Volume 226 (4)
Wiley – Jan 25, 2011and together they define a peculiar microenvironment where one system regulates the other in several ways (Takayanagi, 2007 ). For example, the hematopoietic stem cell niche and the B lymphocyte niche are formed ...
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Recombinant IL-7 enhances the potency of GM-CSF-secreting tumor cell immunotherapy
Li, Betty; VanRoey, Melinda J.; Jooss, Karin
Follow Clinical Immunology , Volume 123 (2)
Elsevier – May 1, 2007), and CD127, the IL-9, IL-15 and IL-21. Though the γ-chain is expressed ubiquitously on lymphocytes, IL-7 is unique, non-redundant and plays an important role in both T- and B-cell development, as well ...
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