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for: phenotypes of mutations in the 5 utr of a limiting transcription
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A long AAAG repeat allele in the 5′ UTR of the ERR-γ gene is correlated with breast cancer predisposition and drives promoter activity in MCF-7 breast cancer cells
C., Galindo; J., McCormick; V., Bubb; D., Abid Alkadem; Long-Shan, Li; L., McIver; A., George; D., Boothman; J., Quinn; M., Skinner; H., Garner
Follow Breast Cancer Research and Treatment , Volume 130 (1)
Springer Journals – Nov 1, 2011We sequenced the 5′ UTR of the estrogen-related receptor gamma gene ( ERR -γ) in ~500 patient and volunteer samples and found that longer alleles of the (AAAG) n microsatellite were statistically ...
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Phenotypes of Mutations in the 5′-UTR of a Limiting Transcription Factor in Aspergillus nidulans Can Be Accounted For by Translational Inhibition and Leaky Scanning
Oestreicher, Nathalie; Scazzocchio, Claudio
Follow Genetics , Volume 181 (4): 1261
Genetics Society of America – Apr 1, 2009diminished transcription of UaY-regulated genes. This mutation introduces an ATG codon 64 bp upstream of the uaY ATG, generating a 68-codon open reading frame (uORFA), overlapping with the uaY ORF. uaY12 ...
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Structural Lability in Stem–Loop 1 Drives a 5′ UTR–3′ UTR Interaction in Coronavirus Replication
Li, Lichun; Kang, Hyojeung; Liu, Pinghua; Makkinje, Nick; Williamson, Shawn T.; Leibowitz, Julian L.; Giedroc, David P.
Follow Journal of Molecular Biology , Volume 377 (3)
Elsevier – Mar 28, 2008between the 5′ UTR and 3′ UTRs and the proteins bound to these UTRs. 13 Many cis -acting sequences in the 5′ UTR have been shown to play an important role in RNA transcription and replication; 14–18 ...
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Comprehensive prediction of mRNA splicing effects of BRCA1 and BRCA2 variants
Mucaki, Eliseos J.; Ainsworth, Peter; Rogan, Peter K.
Follow Human Mutation , Volume 32 (7)
Wiley – May 5, 2011retrieved from BIC (downloaded from on June 8th 2010). BIC transcript coordinates include the 5′ UTR; to align coordinates to the first codon, 119 and 228 nucleotides were respectively subtracted from ...
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The Role of MicroRNAs in Phosphorus Deficiency Signaling
Kuo, Hui-Fen; Chiou, Tzyy-Jen
Follow Plant Physiology , Volume 156 (3): 1016
American Society of Plant Biologist – Jan 1, 2011al., 2005 ; Bari et al., 2006 ; Chiou et al., 2006 ). Multiple sequences complementary to miR399 in the 5′ untranslated region (UTR) of UBC24 direct the cleavage of UBC24 by miR399. The level of UBC24 ...
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Microsatellite markers: an overview of the recent progress in plants
Rajwant, Kalia; Manoj, Rai; Sanjay, Kalia; Rohtas, Singh; A., Dhawan
Follow Euphytica , Volume 177 (3)
Springer Journals – Feb 1, 2011(last 4â5 years) made in plant genetics using SSR markers. Keywords Cross-species transferability à Expressed sequence tags à Molecular markers à Population genetics à Transcription slippage ...
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Dynamic refolding of IFN-γ mRNA enables it to function as PKR activator and translation template
Cohen-Chalamish, Smadar; Hasson, Anat; Weinberg, Dahlia; Namer, Lise Sarah; Banai, Yona; Osman, Farhat; Kaempfer, Raymond
Follow Nature Chemical Biology , Volume 5 (12)
Nature Publishing Group (NPG) – Oct 4, 2009change, A202U, sufficed to abolish PKR activation. The phenotype of A202U was observed also for full-length IFN-γ mRNA transcript (data not shown). Although U171A retained activity, this mutation did ...
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Molecular analysis of 30 Niemann–Pick type C patients from Spain
Macías‐Vidal, J; Rodríguez‐Pascau, L; Sánchez‐Ollé, G; Lluch, M; Vilageliu, L; Grinberg, D; Coll, MJ; Coll, MJ
Follow Clinical Genetics , Volume 80 (1)
Wiley – Jul 6, 2010, genotype–phenotype correlations are limited due to the large number of private mutations. We describe for the first time one homozygous patient for p.I1061T mutation, who presented the severe infantile ...
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Distribution and localization of microsatellites in the Perigord black truffle genome and identification of new molecular markers
Murat, C.; Riccioni, C.; Belfiori, B.; Cichocki, N.; Labbé J.; Morin, E.; Tisserant, E.; Paolocci, F.; Rubini, A.; Martin, F.
Follow Fungal Genetics and Biology , Volume 48 (6)
Elsevier – Jun 1, 2011models, introns, exons, untranslated regions (UTR; both 5′ and 3′ UTRs were considered together) and transposable elements (TE) were downloaded from the Genoscope website (see above) and INRA TuberDB ...
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