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lymphocytes and antibodies that are specifically able to recognize tumor-associated antigens (TAA) are commonly found in cancer patients [2, 3]. Other non-specific but activated immune effector cells ...
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normal tissue antigens to which the individual is normally tolerant. This has led to the concept that effective immunotherapy is not only directed against tumor-specific targets but also can be directed ...
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The antitumor effectiveness of the T-body therapy is strongly related to the composition of the CAR and proper selection of the targeted tumor-associated antigen (TAA). 6,7 The curative effect of this form ...
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that it was, on the contrary, an oncogene. Furthermore, the WT1 protein has proven to be a promising tumor-associated antigen, in which many human leukocyte antigen class I- or II-restricted WT1 epitopes have been identified ...
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antigens, the HPV-16 E6 and E7 proteins contribute to the progression from lesions to malignancy, and are constitutively expressed in HPV-associated cancers throughout the replicative cycle of the virus ...
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were conducted that led to molecular characterization of melanoma-associated antigens (MAA) [2] and allowed new immunotherapy approaches based on the use of well-defined MAA. This was a crucial step ...
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molecules necessary for activation and tolerance to self antigens through the natural T cell selection process [11] . Immunotherapy has begun to target these escape mechanisms through modulation of tumor cell ...
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understand the pathologies to be targeted, as well as how individual subjects may respond to immunotherapies, either in isolation or in combination. Due to the powerful effects of the immune system, one ...
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approaches. Keywords T cell transfer . Cancer . Immunotherapy . Tumor antigen Introduction CD8 T cells play a major role in preventing the development of virus-associated human cancers. Indirect evidence ...