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of proand anti-apoptotic proteins. Also, COX-2 might induce the secretion of tumor growth factors to promote angiogenesis, which accompanied with an increase in protein expression of matrix metalloproteinases ...
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as membrane type-1 matrix metalloproteinase (MT1-MMP), is believed to play a crucial role in facilitating the tumor cells' penetration through extracellular matrix with significant potential for angiogenesis ...
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) are proteolytic enzymes with the ability to remodel the ECM as well as to regulate cellular modulators such as cell-adhesion molecules and growth factor receptors [7] . Membrane type 1 metalloproteinase (MT1-MMP ...
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these actions, MT1-MMP modulates cell migration and has been implicated in tumor growth and dissemination ( Hotary et al., 2000; Seiki and Yana, 2003 ). MT1-MMP over-expression has been detected in tumor cells ...
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and angiogenesis, is expressed on malignant tumor cells and in activated endothelial cells [14] . Furthermore, MT1-MMP is part of the specific transmembrane proteases family that regulates cell growth and invasion ...
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) precursor protein (APP), early growth response 1 (EGR‐1), and matrix metalloproteinase 14 (MMP14 or MT1‐MMP)—that are also implicated in angiogenesis. We further focus on MMP14 given its unique role ...
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, 2006 Methylseleninic acid inhibits PMA-stimulated pro-MMP-2 activation mediated by MT1-MMP expression and further tumor invasion through suppression of NF-kB activation Jong-Min Park, Aeyung Kim, Jang ...
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. These processes required the activities of PKC and ERK1/2 signaling pathways and were coupled with markedly increased MT1-MMP expression. The functional role of MT1-MMP in LTBP-1 release was demonstrated by gene ...
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%). Co-expression of the two proteins was significantly associated with depth of invasion ( P = 0.012). Moreover, proteolytic fragments of Ln-5γ2 and active forms of MT1-MMP were frequently found in tumor ...