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for: molecular physiology of cardiac repolarization
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Calcineurin and Electrical Remodeling in Pathologic Cardiac Hypertrophy
Liu, Hui-Bin; Yang, Bao-Feng; Dong, De-Li
Follow Trends in Cardiovascular Medicine , Volume 20 (5)
Elsevier – Jul 1, 2010of the high mortality in patients with cardiac hypertrophy or heart failure. Interestingly, a recent work reports that physiologic cardiac hypertrophy up-regulates the repolarizing K + channels and L-type Ca 2 ...
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Effect of activation sequence on transmural patterns of repolarization and action potential duration in rabbit ventricular myocardium
Myles, Rachel C.; Bernus, Olivier; Burton, Francis L.; Cobbe, Stuart M.; Smith, Godfrey L.
Follow AJP - Heart and Circulatory Physiology , Volume 299 (6): H1812
The American Physiological Society – Dec 1, 2010, 32 ). Understanding the balance between intrinsic repolarization characteristics and electrotonic influences in ventricular myocardium is therefore central to our understanding of cardiac ...
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Thermal adaptation of the crucian carp (Carassius carassius) cardiac delayed rectifier current, IKs, by homomeric assembly of Kv7.1 subunits without MinK
Hassinen, Minna; Laulaja, Salla; Paajanen, Vesa; Haverinen, Jaakko; Vornanen, Matti
Follow AJP - Regulatory, Integrative and Comparative Physiology , Volume 301 (1): R255
The American Physiological Society – Jul 1, 2011.). I Ks is an important repolarizing current that prevents excessive prolongation of cardiac action potential, but it is extremely slowly activating when expressed in typical molecular composition ...
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Ionic mechanisms of cellular electrical and mechanical abnormalities in Brugada syndrome
Dong, Min; Niklewski, Paul J.; Wang, Hong-Sheng
Follow AJP - Heart and Circulatory Physiology , Volume 300 (1): H279
The American Physiological Society – Jan 1, 2011Abstract The Brugada syndrome (BrS) is a right ventricular (RV) arrhythmia that is responsible for up to 12% of sudden cardiac deaths. The aims of our study were to determine the cellular mechanisms ...
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HERG1 channelopathies
Michael, Sanguinetti
Follow Pflügers Archiv European Journal of Physiologyl of Physiology , Volume 460 (2)
Springer Journals – Jul 1, 2010that encodes hERG1) causes LQT2, one of the most common forms of long QT syndrome, a disorder of cardiac repolarization that predisposes affected subjects to ventricular arrhythmia and increases the risk ...
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Overexpression of type 1 angiotensin II receptors impairs excitation-contraction coupling in the mouse heart
Rivard, Katy; Grandy, Scott A.; Douillette, Annie; Paradis, Pierre; Nemer, Mona; Allen, Bruce G.; Fiset, Céline
Follow AJP - Heart and Circulatory Physiology , Volume 301 (5): H2018
The American Physiological Society – Nov 1, 2011handling cardiac contraction Copyright © 2011 the American Physiological Society « Previous | Next Article » Table of Contents This Article Published online before print August 2011 , doi: 10.1152/ajpheart ...
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Electrocardiographic assessment for therapeutic proteins—scientific discussion
Rodriguez, Ignacio; Erdman, Andrew; Padhi, Desmond; Garnett, Christine E.; Zhao, Hong; Targum, Shari L.; Balakrishnan, Suchitra; Strnadova, Colette; Viner, Norman; Geiger, Mary Jane; Newton-Cheh, Christopher; Litwin, Jeffrey; Pugsley, Michael K.; Sager, Philip T.; Krucoff, Mitchell W.; Finkle, John K.
Follow American Heart Journal , Volume 160 (4)
Elsevier – Oct 1, 2010Requirements for Registration of Pharmaceuticals for Human Use E14 guideline recommends a dedicated study to evaluate drug-induced effects on cardiac repolarization (“thorough QT/QTc study”). There has been ...
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Molecular Physiology of Cardiac Repolarization
Nerbonne, Jeanne M.; Kass, Robert S.
Follow Physiological Reviews , Volume 85 (4): 1205
The American Physiological Society – Oct 1, 2005and to the generation of normal cardiac rhythms. Changes in channel functioning, resulting from inherited or acquired disease, affect action potential repolarization and can lead to the generation of life-threatening ...
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In vivo dispersion in repolarization and arrhythmias in the human heart
Opthof, Tobias
Follow AJP - Heart and Circulatory Physiology , Volume 290 (1): H77
The American Physiological Society – Jan 1, 2006In vivo dispersion in repolarization and arrhythmias in the human heart Tobias Opthof Experimental and Molecular Cardiology Groups, Academic Medical Center, Amsterdam; and Department of Medical ...
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Pore mutants of HERG and KvLQT1 downregulate the reciprocal currents in stable cell lines
Ren, Xiao-Qin; Liu, Gong Xin; Organ-Darling, Louise E.; Zheng, Renjian; Roder, Karim; Jindal, Hitesh K.; Centracchio, Jason; McDonald, Thomas V.; Koren, Gideon
Follow AJP - Heart and Circulatory Physiology , Volume 299 (5): H1525
The American Physiological Society – Nov 1, 2010Physiological Society Abstract We previously reported a transgenic rabbit model of long QT syndrome based on overexpression of pore mutants of repolarizing K + channels KvLQT1 (LQT1) and HERG (LQT2 ...
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