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) is cleaved in the trans-Golgi network into disulï¬de-linked GP1 and GP2 . GP1 binds to the unknown host cell receptor, and GP2 mediates fusion of the viral and cell membranes. Filoviral entry mechanisms ...
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with the expression level of TRAIL receptors. These results establish that besides HBx, preS2 viral proteins are also involved in enhancing TRAIL-induced hepatocyte apoptosis. The novel role of preS2 would be useful ...
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Activated hepatic stellate cells which contribute to liver fibrosis have represented an important target for antifibrotic therapy. In this study, we found that TRAIL inhibited PI3K/Akt-dependent FoxO ...
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due to its broad epidemiology, which ranges from chronic exposure to alcohol or aflatoxin B1 to fatty liver disease and metabolic disorders, as well as hepatitis viral infections including hepatitis B ...
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The TNF-related apoptosis-inducing ligand (TRAIL) has recently been implicated in the death of hepatocytes under infectious but not normal conditions. Infectious agents, such as hepatitis B virus ...
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., 2007 ). TRAIL, via its receptor DR5, selectively induces apoptosis of transformed and virally infected hepatocytes, and NF-κB–dependent signaling counteracts its detrimental effects ( Luo et al., 2004 ...
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implicating hepatic natural killer (NK) cells in liver damage [5] . Hepatic NK cells kill freshly isolated hepatocytes by a TRAIL/TRAIL receptor (TRAILR) pathway in a polyinosinic–polycytidylic acid (poly I:C ...
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(CD226) [10–12] . Among these, NKG2D is the most well-defined receptor, which binds its ligands (e.g., MICA/B and ULBP in humans, RAE-1 and MULT1 in mice) that are expressed on target cells ...
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indicated that the death receptor pathway was mainly involved and regulated by PPAR-γ and p53 in the process of apoptosis triggered by C/EBP-α in HSCs. There is increasing attention on the hepatic ...