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Protein ubiquitination is central to the regulation of various pathways in eukaryotes. The process of ubiquitination and its cellular outcome were investigated in hundreds of proteins to date ...
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is likely to play a greater role in melanoma management and should be considered as a treatment option. Introduction In their classic 1946 text, McKee and Cipollaro (1) wrote a disheartening chapter ...
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In addition to its role as a toxicological signal mediator, the Aryl Hydrocarbon Receptor (AHR) is also a transcription factor known to regulate cellular responses to oxidative stress ...
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, it is equally important to unravel the biological relationship between ubiquitylated substrates and the ubiquitin conjugation machinery. Relevant to this, we discuss the role of affinity purification‐MS (AP‐MS ...
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Cellular pathways relay information through dynamic protein interactions. We have assessed the kinetic properties of the murine double minute protein (MDM2) and von Hippel-Lindau (VHL) ubiquitin ...
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>Introduction The ubiquitin–proteasome pathway (UPP) is a highly selective proteolytic system that plays crucial roles in protein quality control, cell cycle control, proliferation, development, signal ...
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Nonproteolytic ubiquitylation of chromatin surrounding deoxyribonucleic acid double-strand breaks (DSBs), mediated by the RNF8/RNF168 ubiquitin ligases, plays a key role in recruiting repair factors ...
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recognized outcome of CRL-dependent protein ubiquitination ( Hershko and Ciechanover, 1998 ), protein ubiquitination also regulates a number of proteasome-independent cellular processes, including DNA repair ...
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protein. Indeed, ubiquitination is involved in most cellular processes ranging from protein degradation and receptor trafficking to innate immunity [1–5] . Not surprisingly, viruses have evolved strategies ...