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. Unlike clustering of HLA-C at the immune synapse, intercellular transfer of HLA-C is dependent on NK cell ATP, but not target cell ATP. However, the intercellular transfer of HLA-C is not dependent ...
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conditions: (1) Neurons, glia cells and immune cells share intercellular signals like hormones, neurotransmitters and modulators, cytokines and chemokines, and they express respective receptors ...
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in natural killer (NK) cells contacting target cells expressing cognate major histocompatibility complex class I proteins revealed that inhibitory signaling is spatially restricted to the immune synapse ...
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The intercellular transfer of cell membranes and integral membrane proteins has been reported for a wide variety of cells, including cells involved in the immune response, and the passively acquired ...
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and allow a direct physical connection to the plasma membranes of remote cells. TNTs and associated structures serve as mediators for intercellular transfer of organelles as well as membrane components ...
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, and they can be up to several cell diameters long [7] . In the case of immune cells such as macrophages, Epstein Barr Virus-transformed B cells and human peripheral blood NK cells, the average length of TNTs ...
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activation clusters (SMACs), an arrangement that has been called the immune synapse (IS).2â4 The NK cell IS has been intensely studied in recent years leading to an increased knowledge about its function ...
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communication in the immune system ( 1 ). Immunological synapses serve as the anatomical substrate of T cell–APC communication during the priming of naive T cells and during the effector phase of T and NK cells ...
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compartmentalization and timed signaling is acutely clear during T and NK cell activation. Immune surveillance by lymphocytes involves formation of distinct intercellular contacts or immune synapses. Here, multiple ...