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for: inducible activation of akt increases skeletal muscle mass and force
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Inducible activation of Akt increases skeletal muscle mass and force without satellite cell activation
Blaauw, Bert; Canato, Marta; Agatea, Lisa; Toniolo, Luana; Mammucari, Cristina; Masiero, Eva; Abraham, Reimar; Sandri, Marco; Schiaffino, Stefano; Reggiani, Carlo
Follow The FASEB Journal , Volume 23 (11): 3896
Fed of American Socs for Experimental Biology – Nov 1, 2009., Abraham, R., Sandri, M., Schiaffino, S., Reggiani, C. Inducible activation of Akt increases skeletal muscle mass and force without satellite cell activation. BrdU angiogenesis skinned fibers nuclear ...
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Akt activation induces hypertrophy without contractile phenotypic maturation in airway smooth muscle
Ma, Lan; Brown, Melanie; Kogut, Paul; Serban, Karina; Li, Xiaojing; McConville, John; Chen, Bohao; Bentley, J. Kelley; Hershenson, Marc B.; Dulin, Nickolai; Solway, Julian; Camoretti-Mercado, Blanca
Follow AJP - Lung Cellular and Molecular Physiology , Volume 300 (5): L701
The American Physiological Society – May 1, 2011in, among other effects, markedly reduced skeletal muscle mass attributable to reduced myocyte size ( 24 ). Conversely, forced overexpression of constitutively active Akt increases overall heart size ...
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Mitogen-activated protein kinase signaling is necessary for the maintenance of skeletal muscle mass
Shi, Hao; Scheffler, Jason M.; Zeng, Caiyun; Pleitner, Jonathan M.; Hannon, Kevin M.; Grant, Alan L.; Gerrard, David E.
Follow AJP - Cell Physiology , Volume 296 (5): C1040
The American Physiological Society – May 1, 2009/2 phosphorylation increases concurrently with p38 activation in a hindlimb suspension-induced atrophy model ( 19 ). In this report, we examined the role of MAPK signaling in the maintenance of muscle ...
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Glycogen synthase kinase-3β is required for the induction of skeletal muscle atrophy
Verhees, Koen J. P.; Schols, Annemie M. W. J.; Kelders, Marco C. J. M.; Op den Kamp, Céline M. H.; van der Velden, Jos L. J.; Langen, Ramon C. J.
Follow AJP - Cell Physiology , Volume 301 (5): C995
The American Physiological Society – Nov 1, 2011Abstract Skeletal muscle atrophy commonly occurs in acute and chronic disease. The expression of the muscle-specific E3 ligases atrogin-1 (MAFbx) and muscle RING finger 1 (MuRF1) is induced ...
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AMPK promotes skeletal muscle autophagy through activation of forkhead FoxO3a and interaction with Ulk1
Sanchez, Anthony MJ; Csibi, Alfredo; Raibon, Audrey; Cornille, Karen; Gay, Stéphanie; Bernardi, Henri; Candau, Robin
Follow Journal of Cellular Biochemistry , Volume 113 (2)
Wiley – Jan 5, 2012the overall muscle fiber size. AMP‐activated protein kinase (AMPK), a sensor of cellular energy status, was recently shown to increase myofibrillar protein degradation through the expression of MAFbx and MuRF1 ...
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Recovery of skeletal muscle mass after extensive injury: positive effects of increased contractile activity
Richard-Bulteau, Hélène; Serrurier, Bernard; Crassous, Brigitte; Banzet, Sébastien; Peinnequin, André; Bigard, Xavier; Koulmann, Nathalie
Follow AJP - Cell Physiology , Volume 294 (2): C467
The American Physiological Society – Feb 1, 2008( 16 , 41 ). IGF-I activates the phosphatidylinositol 3-kinase (PI3K)-protein kinase B (Akt) pathway, which is necessary and sufficient to induce skeletal muscle hypertrophy ( 20 ). Akt phosphorylation ...
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Decreased specific force and power production of muscle fibers from myostatin-deficient mice are associated with a suppression of protein degradation
Mendias, Christopher L.; Kayupov, Erdan; Bradley, Joshua R.; Brooks, Susan V.; Claflin, Dennis R.
Follow Journal of Applied Physiology , Volume 111 (1): 185
The American Physiological Society – Jul 1, 2011force (sF o ; F o normalized by muscle cross-sectional area). The reason for the reduction in sF o was not known. Studies in myotubes indicate that inhibiting myostatin may increase muscle mass ...
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Targeted ablation of TRAF6 inhibits skeletal muscle wasting in mice
Paul, Pradyut K.; Gupta, Sanjay K.; Bhatnagar, Shephali; Panguluri, Siva K.; Darnay, Bryant G.; Choi, Yongwon; Kumar, Ashok
Follow The Journal of Cell Biology , Volume 191 (7): 1395
Rockefeller University Press – Dec 27, 2010transcription factor that regulates the expression of a large number of genes, including those involved in skeletal muscle proteolysis and fibrosis ( Kumar et al., 2004 ). Increased activation of NF-κB has been ...
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Contraction-stimulated glucose transport in rat skeletal muscle is sustained despite reversal of increased PAS-phosphorylation of AS160 and TBC1D1
Funai, Katsuhiko; Cartee, Gregory D.
Follow Journal of Applied Physiology , Volume 105 (6): 1788
The American Physiological Society – Dec 1, 2008+ /calmodulin-dependent kinase II; Akt INSULIN OR CONTRACTILE ACTIVITY each result in a rapid increase in glucose transport by isolated rat skeletal muscle that can be sustained for at least 60 min ...
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Effects of spaceflight on murine skeletal muscle gene expression
Allen, David L.; Bandstra, Eric R.; Harrison, Brooke C.; Thorng, Seiha; Stodieck, Louis S.; Kostenuik, Paul J.; Morony, Sean; Lacey, David L.; Hammond, Timothy G.; Leinwand, Leslie L.; Argraves, W. Scott; Bateman, Ted A.; Barth, Jeremy L.
Follow Journal of Applied Physiology , Volume 106 (2): 582
The American Physiological Society – Feb 1, 2009and/or expression of genes involved in PI3-kinase/Akt/mTOR signaling. Skeletal muscle mass is also negatively regulated by the myostatin pathway. Inactivation of myostatin through naturally occurring or targeted ...
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