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Research highlights &z.rtrif; Hormone response element binding proteins mediate nuclear receptor gene activation. &z.rtrif; Dysregulated vitamin D response element binding protein results in hormone ...
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. The requirements for direct VDR DNA binding and for heterodimer formation with RXR in the downregulation of genes by vitamin D have not been resolved and may be target gene specific. In the case of CYP27B1 ...
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hormone receptors, in particular the family of retinoid X receptors. This complex then binds to special DNA sequences called vitamin D response elements (VDREs) in the promoters (and other regions) of genes ...
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that binds to vitamin D response elements (VDRE) in the promoter region of target genes to alter transcriptional events within target cells. VDR has been identified in over 30 tissues/organs of man since 1969 ...
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. Their overexpression increases vitamin D receptor (VDR)-directed target gene expression. We found that these intracellular vitamin D binding proteins (IDBPs) are homologous to proteins in the heat shock protein-70 ...
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receptor with a DNA-binding domain that acts through vitamin D response elements located near the start site of target genes [1] . The presence of the VDR in pancreatic β -cells [2] supports the findings ...
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heterodimerization, usually with the retinoid X receptor (RXR), and binds to specific DNA sequences (vitamin-D response elements, VDREs) located in promoter regions, thereby controlling the transcription of target ...
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investigate the regulation of the Mdm2 gene expression in osteoblast cells. We observed that Mdm2 expression could be upregulated by vitamin D3 and further identified a vitamin D receptor (VDR) responsive ...
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The vitamin D receptor (VDR) typically binds DNA in a heterodimer complex with the retinoid X receptor (RXR) to direct repeat sequences separated by three base pairs, or vitamin D response elements ...