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Functional implications of the influence of ABCA1 on lipid microenvironment at the plasma membrane: a biophysical study
Zarubica, Ana; Plazzo, Anna Pia; Stöckl, Martin; Trombik, Tomasz; Hamon, Yannick; Müller, Peter; Pomorski, Thomas; Herrmann, Andreas; Chimini, Giovanna
Follow The FASEB Journal , Volume 23 (6): 1775
Fed of American Socs for Experimental Biology – Jun 1, 2009.—Zarubica, A., Plazzo, A. P., Stöckl, M., Trombik, T., Hamon, Y., Müller, P., Pomorski, T., Herrmann, A., Chimini, G. Functional implications of the influence of ABCA1 on lipid microenvironment at the plasma ...
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Transport of lipids by ABC proteins: Interactions and implications for cellular toxicity, viability and function
Aye, Irving L.M.H.; Singh, Ambika T.; Keelan, Jeffrey A.
Follow Chemico-Biological Interactions , Volume 180 (3)
Elsevier – Aug 14, 2009, the complex interactions between ABC transporters and their lipid/sterol substrates will be discussed and analyzed in the context of their relevance to cellular function, toxicity and apoptosis. 1 ...
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Transcriptional regulatory networks in lipid metabolism control ABCA1 expression
Schmitz, Gerd; Langmann, Thomas
Follow Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids , Volume 1735 (1)
Elsevier – Jun 15, 2005vascular dementia and Alzheimer's disease [21,22] , indicating that lipid homeostasis is also a critical factor for peripheral vascular disorders.3 Functions of ABCA1 and ABCG1 ...
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The role of ATP-binding cassette transporter A1 in Alzheimer's disease and neurodegeneration
Koldamova, Radosveta; Fitz, Nicholas F.; Lefterov, Iliya
Follow Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids , Volume 1801 (8)
Elsevier – Aug 1, 2010, and ABCA1 controlled lipidation which can influence Aβ aggregation and amyloid clearance. This review will summarize the results of research on ABCA1, particularly related to AD and neurodegeneration. 1 ...
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Membrane receptors and transporters involved in the function and transport of vitamin A and its derivatives
Sun, Hui
Follow Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids , Volume 1821 (1)
Elsevier – Jan 1, 2012of molecules such as sugars, peptides, metals, lipids, and drugs across membranes. CFTR, a member of the ABC transporter family, even functions as a chloride channel. ABCA4 is most homologous to ABCA1 ...
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A novel intronic polymorphism of ABCA1 gene reveals risk for sporadic Alzheimer's disease in Chinese
Chu, Leung Wing; Li, Yan; Li, Zhong; Tang, Alan YB; Cheung, Bernard MY; Leung, Raymond YH; Yik, Ping‐Yiu; Jin, Dong‐Yan; Song, You‐Qiang
Follow American Journal of Medical Genetics part B , Volume 144B (8)
Wiley – Nov 13, 2007Recent genetic studies have shown that variants of the ATP‐binding cassette transporter A1, ABCA1, may be implicated in the pathogenesis of Alzheimer's disease (AD). In this case‐control study ...
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Phytosterols differentially influence ABC transporter expression, cholesterol efflux and inflammatory cytokine secretion in macrophage foam cells
Sabeva, Nadezhda S.; McPhaul, Christopher M.; Li, Xiangan; Cory, Theodore J.; Feola, David J.; Graf, Gregory A.
Follow The Journal of Nutritional Biochemistry , Volume 22 (8)
Elsevier – Aug 1, 2011be either beneficial or deleterious with respect to atherosclerosis, but little is known concerning their effects on macrophage function. The effects of phytosterols on ABCA1 and ABCG1 abundance, cholesterol ...
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Association of ABCA1 with late-onset Alzheimer’s disease is not observed in a case-control study
Li, Yonghong; Tacey, Kristina; Doil, Lisa; Luchene, Ryan van; Garcia, Veronica; Rowland, Charles; Schrodi, Steve; Leong, Diane; Lau, Kit; Catanese, Joe; Sninsky, John; Nowotny, Petra; Holmans, Peter; Hardy, John; Powell, John; Lovestone, Simon; Thal, Leon; Owen, Michael; Williams, Julie; Goate, Alison; Grupe, Andrew
Follow Neuroscience Letters , Volume 366 (3)
Elsevier – Aug 19, 2004that functions as a cholesterol efflux pump in the cellular lipid removal pathway, thus making ABCA1 a potential AD candidate gene. The gene encoding ABCA1 is located near the previously detected AD linkage peak ...
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Formation and function of apolipoprotein E-containing lipoproteins in the nervous system
Vance, Jean E.; Hayashi, Hideki
Follow Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids , Volume 1801 (8)
Elsevier – Aug 1, 2010. Alterations in the metabolism of lipids, particularly cholesterol, have been implicated in the pathogenesis of several neurodegenerative disorders including Alzheimer disease (AD), Niemann–Pick C ...
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ABCA1 mediates high-affinity uptake of 25-hydroxycholesterol by membrane vesicles and rapid efflux of oxysterol by intact cells
Tam, Shui-Pang; Mok, Leo; Chimini, Giovanna; Vasa, Monika; Deeley, Roger G.
Follow AJP - Cell Physiology , Volume 291 (3): C490
The American Physiological Society – Sep 1, 2006function was unknown ( 34 ). Defects in the ABCA1 gene were subsequently shown to be the cause of Tangier disease, which is characterized by a lack, or abnormally low level, of high-density lipoprotein (HDL ...
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