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for: extracellular cadherin repeat domains ec1 and ec5 of t cadherin are
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Extracellular cadherin repeat domains EC1 and EC5 of T-cadherin are essential for its ability to stimulate angiogenic behavior of endothelial cells
Joshi, Manjunath B.; Kyriakakis, Emmanouil; Pfaff, Dennis; Rupp, Katharina; Philippova, Maria; Erne, Paul; Resink, Thérèse J.
Follow The FASEB Journal , Volume 23 (11): 4011
Fed of American Socs for Experimental Biology – Nov 1, 2009angiogenesis.—Joshi, M. B., Kyriakakis, E., Pfaff, D., Rupp, K., Philippova, M., Erne, P., Resink, T. J. Extracellular cadherin repeat domains EC1 and EC5 of T-cadherin are essential for its ability to stimulate ...
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Increasing Paracellular Porosity by E-Cadherin Peptides: Discovery of Bulge and Groove Regions in the EC1-Domain of E-Cadherin
Ernawati, Sinaga; Seetharama, Jois; Mike, Avery; Irwan, Makagiansar; Usman, Tambunan; Kenneth, Audus; Teruna, Siahaan
Follow Pharmaceutical Research , Volume 19 (8)
Springer Journals – Aug 1, 2002membrane-spanning segment, and a relatively short cytoplasmic domain (Fig. 1) (1,2,13â15). The extracellular domain has five tandem repeats called EC1-to-EC5 domains, which bind to calcium ions (16 ...
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Cadherin 13 in cancer
Andreeva, Alexandra V.; Kutuzov, Mikhail A.
Follow Genes, Chromosomes and Cancer , Volume 49 (9)
Wiley – May 19, 2010) Domain organization of classical and nonclassical cadherins and some of their intracellular interacting partners. Gray circles, extracellular subdomains (cadherin repeats), present in various numbers (5–34 ...
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Sequence and Structural Determinants of Strand Swapping in Cadherin Domains: Do All Cadherins Bind Through the Same Adhesive Interface?
Posy, Shoshana; Shapiro, Lawrence; Honig, Barry
Follow Journal of Molecular Biology , Volume 378 (4)
Elsevier – May 9, 2008extracellular cadherin (EC) domains. With the exceptions of the seven-pass flamingo cadherins and truncated (T-) cadherin, which is GPI-anchored, cadherins are single-pass transmembrane proteins that contain ...
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Mutation Analysis of Cadherin-4 Reveals Amino Acid Residues of EC1 Important for the Structure and Function
Kitagawa, Michihiro; Natori, Michiya; Murase, Sachiko; Hirano, Shinji; Taketani, Shigeru; Suzuki, Shintaro T.
Follow Biochemical and Biophysical Research Communications , Volume 271 (2)
Elsevier – May 10, 2000cadherin repeat of extracellular domain; HBS, Hepes-buffered saline; PAGE, polyacrylamide gel electrophoresis; PBS, phosphate-buffered saline. 1 Present address: Department of Biology, California Institute ...
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Effects of An E-cadherin-Derived Peptide on the Gene Expression of Caco-2 Cells
Anna, Calcagno; Jennifer, Fostel; Eric, Reyner; Ernawati, Sinaga; James, Alston; William, Mattes; Teruna, Siahaan; Joseph, Ware
Follow Pharmaceutical Research , Volume 21 (11)
Springer Journals – Nov 1, 2004. (e-mail: calcagnoa@ mail.nih.gov) These repeats are referred to as EC1 through EC5. The EC1 repeat contains the conserved His-Ala-Val (HAV) sequence, which is involved in the homotypic binding ...
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Two Cell Adhesion Molecules, Nectin and Cadherin, Interact through Their Cytoplasmic Domain–Associated Proteins
Tachibana, Kouichi; Nakanishi, Hiroyuki; Mandai, Kenji; Ozaki, Kumi; Ikeda, Wataru; Yamamoto, Yasunori; Nagafuchi, Akira; Tsukita, Shoichiro; Takai, Yoshimi
Follow The Journal of Cell Biology , Volume 150 (5): 1161
Rockefeller University Press – Sep 4, 2000–cell AJs, but also in the organization of tight junctions (TJs; Takeichi 1991 , Takeichi 1995 ; Gumbiner 1996 , Gumbiner 2000 ). Cadherin consists of five extracellular tandemly repeated domains, EC1-EC5 ...
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Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members 1 1 Edited by M. Yaniv
Nollet, Friedel; Kools, Patrick; van Roy, Frans
Follow Journal of Molecular Biology , Volume 299 (3)
Elsevier – Jun 9, 2000110 amino acid residues with conserved calcium binding sequence motifs, i.e. four homologous cadherin repeats (EC1 to EC4) and one less related membrane-proximal extracellular domain (EC5 or MPED ...
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Molecular perspective on tight-junction assembly and epithelial polarity
Miyoshi, Jun; Takai, Yoshimi
Follow Advanced Drug Delivery Reviews , Volume 57 (6)
Elsevier – Apr 25, 2005and best-characterized member of the family. The extracellular portion of E-cadherin contains five-tandemly-repeated ectodomains, EC1–EC5, which bind Ca 2+ and serve as a template for homophilic binding ...
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