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cancer in vitiligo.—Salem, M. M. A. E. L., Shalbaf, M., Gibbons, N. C. J., Chavan, B., Thornton, J. M., Schallreuter, K. U. Enhanced DNA binding capacity on up-regulated epidermal wild-type p53 in vitiligo ...
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in DNA methylation that are frequently up regulated in lung cancer and associated with poor prognosis. It was found that the expression of miR-29s is inversely correlated to DNMT3A and -3B in lung cancer ...
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with wild-type mice, develops an altered intracellular redox state due to accumulation of NADH and reduced levels of NAD/NADH. In comparison to NQO1 wild-type mice, NQO1-null mice failed to exhibit p53 ...
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of other genetic changes are necessary to explain the phenotypic variation of the disease and the development of amyloidosis. In FMF patients, the up‐regulation of neutrophil and monocyte phagocytic activity ...
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value of the analysis of phosphorylation states of signalling molecules such as epidermal growth factor receptor, mitogen-activated protein kinase, p53, etc. Some results, however, appear equivocal ...
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with mutant p53 also have greater DNA indices than dysplasias with wild‐type (wt) p53 genes [Walker et al., 1994 ]. Mutant human p53 cDNA transfected into non‐tumorigenic human bronchial epithelial cells ...
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that only angiogenin and VEGF were up-regulated, and other growth factors tested (e.g., bFGF, PDGF, TGFb) in parallel showed minimal elevation. Epidermal growth factor (EGF), when bound to its receptor EFGR ...
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nonfunctional and loses its checkpoint control, p53 can no longer stops cells from dividing allowing cancerous cells to replicate more readily. 195,,196 Half of all human tumors are wild-type p53 so rather than ...
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nerves in the upper and lower dermis, as well as epithelium, supports the capacity for these neuropeptides to participate in sensory nerve transmission as well as interaction with epidermal and dermal ...
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modulates the expression of Th1/Th2 transcription factors in human T cells: HSP60 down-regulates T-bet, NF-κB, and NFATp, and up-regulates GATA-3, leading to decreased secretion of TNFα and IFNγ and enhanced ...
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