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Enhanced activation of a "nutrient-sensing" pathway with age contributes to insulin resistance Francine H. Einstein * ,† , Sigal Fishman * , Jeffery Bauman * , Reid F. Thompson * , Derek M. Huffman ...
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, but poorly deï¬ned, channel in the glucose regulatory network. The Gpr1/Gpa2 Circuit Gpr1 and Gpa2 deï¬ne a nutrient-sensing pathway that works in parallel with Ras to activate PKA (Figure 1). Gpa2 ...
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of plentiful nutrient supply ( 9 , 21 , 97 ). The amino acid sensing mechanisms that lie upstream of the GCN2 and TOR pathways are beginning to be revealed ( 9 , 98 ) and amino acid transporters, as the initial ...
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pathway acting through PI3K/PKB and FOXO. Loss of PKB signaling contributes to diabetes, whereas gain of function of PKB drives cancer. Enhanced FOXO activity, at least in model organism contributes ...
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in mammalian systems are taking us closer to the goal of being able to employ our understanding of DR to postpone aging and age-related diseases in humans.The contribution of individual nutrients ...
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expression and the concerted activities of interconnected genes controlled by NRs. Finally, we discuss the hypothesis that this sex-dimorphic NR “interactome” targets selected pathways in the liver ...
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via nutrient sensing pathways is involved during a bee’s shift to foraging behavior ( Ament , 2008 ) and reduced signaling by the same pathways may aid reversal.Social stress, stress reactivity ...
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Summary Regulator of G‐protein signaling (RGS) proteins contribute to G‐protein signaling pathways as activators or repressors with GTPase‐activating protein (GAP) activity. To characterize whether ...
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contributes to enhanced cell excitability and GLP-1 secretion [31]. By contrast, studies of GIP secretion using an STC-1 subclone (GIP/ins) suggested that nutrient sensing arises from the metabolic inhibition ...
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anti‐aging action remains unknown.DR decreases available nutrients, raising the possibility that a nutrient‐sensing pathway might mediate the anti‐aging effect of DR. Two signaling pathways ...
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