Did you mean: endogenous nitrite mediated mitochondrial dysfunction in rat
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, deoxyribonucleic acid-strand breakage, and inhibition of mitochondrial respiration, leading to tissue injury (26–29) . For example, endogenous formation of peroxynitrite contributes to myocardial stunning ...
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mediator of cellular damage in a wide range of conditions. Recent evidence indicates that most of the cytotoxicity attributed to NO is rather due to peroxynitrite, produced from the diffusion-controlled ...
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Highlights ► H 2 S protects PC12 cells against formaldehyde (FA)-induced cytotoxicity and apoptosis. ► H 2 S prevents FA-caused mitochondrial membrane potential loss and cytochrome c release. ► H 2 S ...
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related to a possible activation of mitochondrial nitric oxide synthase (mNOS). We show here that the upregulation of oxide mNOS and peroxynitrite formation in cisplatin treatment are key events ...
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uniporter driven by the proton electrochemical gradient and Ca2+ efflux is mainly mediated by Na+/Ca2+ exchanger (NCX), thus leading to the concept of a continuous Ca2+ recycling across the mitochondrial ...
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peroxynitrite (ONOO ). There is also evidence that NO can be produced endogenously in mitochondria by a mitochondrial nitric oxide synthase (mtNOS) ( Giulivi, 2003 ).Excessive ROS production from ...
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Ischemia-reperfusion generates peroxynitrite (ONOO – ), which interacts with many of the systems altered by ischemia-reperfusion. This study examines the influence of endogenously produced ONOO ...
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of arginase, an endogenous competitor of eNOS for L-arginine, may represent one such mechanism in that ischaemia/reperfusion (I/R) has been found to inhibit the NO-mediated coronary arteriole dilation ...
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occurs spontaneously with advancing age in rat and mouse midbrain and hippocampal tissues. These findings further connect mitochondrial dysfunction to aging, a principle risk factor for neurodegeneration ...