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for: effect of a high dose of glucosamine on systemic and tissue
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Effect of a high dose of glucosamine on systemic and tissue inflammation in an experimental model of atherosclerosis aggravated by chronic arthritis
Largo, Raquel; Martínez-Calatrava, María José; Sánchez-Pernaute, Olga; Marcos, M. Esther; Moreno-Rubio, Juan; Aparicio, César; Egido, Jesús; Herrero-Beaumont, Gabriel
Follow AJP - Heart and Circulatory Physiology , Volume 297 (1): H268
The American Physiological Society – Jul 1, 2009Abstract Glucosamine sulfate (GS) is a glycosaminoglycan with anti-inflammatory and immunoregulatory properties. Here we set out to explore the effect of GS administration on markers of systemic ...
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Glucosamine attenuates increases of intraabdominal fat, serum leptin levels, and insulin resistance induced by a high-fat diet in rats
Barrientos, Cornelio; Racotta, Radu; Quevedo, Lucía
Follow Nutrition Research , Volume 30 (11)
Elsevier – Nov 1, 2010that the administration of GlcN to rats receiving a high-fat (HF) diet may potentiate the effects of an HF diet on glucose tolerance and other metabolic variables. To evaluate this relationship, 2 groups of rats were fed ...
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A 4-deoxy analogue of N -acetyl- d -glucosamine inhibits heparan sulphate expression and growth factor binding in vitro
van Wijk, Xander M.R.; Oosterhof, Arie; van den Broek, Sebastiaan A.M.W.; Griffioen, Arjan W.; ten Dam, Gerdy B.; Rutjes, Floris P.J.T.; van Delft, Floris L.; van Kuppevelt, Toin H.
Follow Experimental Cell Research , Volume 316 (15)
Elsevier – Sep 10, 2010and angiogenesis, makes it an appealing target for cancer therapy. To target the biosynthesis of HS by interfering with its chain elongation, a 4-deoxy analogue of N -acetyl- d -glucosamine (4-deoxy-GlcNAc ...
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Impact of high-dose, chemically modified sulfamidase on pathology in a murine model of MPS IIIA
Rozaklis, Tina; Beard, Helen; Hassiotis, Sofia; Garcia, Antony R.; Tonini, Matthew; Luck, Amanda; Pan, Jing; Lamsa, Justin C.; Hopwood, John J.; Hemsley, Kim M.
Follow Experimental Neurology , Volume 230 (1)
Elsevier – Jul 1, 2011mice due to an inability to traverse the blood–brain barrier; however high-dose treatment or administration of enzyme that has been chemically modified to remove mannose-6-phosphate glycans has been ...
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Hydrolyzed eggshell membrane immobilized on phosphorylcholine polymer supplies extracellular matrix environment for human dermal fibroblasts
Eri, Ohto-Fujita; Tomohiro, Konno; Miho, Shimizu; Kazuhiko, Ishihara; Toshihiro, Sugitate; Jun, Miyake; Kotaro, Yoshimura; Kaori, Taniwaki; Takashi, Sakurai; Yukio, Hasebe; Yoriko, Atomi
Follow Cell and Tissue Research , Volume 345 (1)
Springer Journals – Jul 1, 2011these processes, tissue disruption has to be repaired and filled by ECM molecules (e.g., mainly collagen) deposited by dermal fibroblast cells. In this study, we have aimed to construct a model system ...
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Sulfated glucosamine inhibits oxidation of biomolecules in cells via a mechanism involving intracellular free radical scavenging
Mendis, Eresha; Kim, Moon-Moo; Rajapakse, Niranjan; Kim, Se-Kwon
Follow European Journal of Pharmacology , Volume 579 (1)
Elsevier – Jan 28, 2008effective radical scavenging potential of sulfated glucosamine in cellular and non-cellular systems. More importantly, NF-κB reporter gene assay and western blot analysis revealed that sulfated glucosamine ...
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Water-soluble derivatives of chitosan as a target delivery system of 99m Tc to some organs in vivo for nuclear imaging and biodistribution
Dalia, Hawary; Mohamed, Motaleb; Hamed, Farag; Osiris, Guirguis; Maher, Elsabee
Follow Journal of Radioanalytical and Nuclear Chemistry , Volume 290 (3)
Springer Journals – Dec 1, 2011dose per gram of tissue (%ID/g). It has been found that the biodistribution of the two compounds and the pattern of their liver uptake were markedly different. The present study demonstrates a high ...
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Biopolymeric nifedipine powder for acceleration of wound healing
Samy, Wael; Elgindy, Nazik; El-Gowelli, Hanan M.
Follow International Journal of Pharmaceutics , Volume 422 (1)
Elsevier – Jan 17, 2012of different formulations with different release rates on the ability of NF to accelerate wound healing or the effect of the selected doses of NF that accelerated wound healing on systemic blood pressure. ...
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Hyaluronic acid–paclitaxel: effects of intraperitoneal administration against CD44(+) human ovarian cancer xenografts
Ilaria, Stefano; Alessandra, Battaglia; Gian, Zannoni; Maria, Prisco; Andrea, Fattorossi; Daniele, Travaglia; Silvia, Baroni; Davide, Renier; Giovanni, Scambia; Cristiano, Ferlini; Daniela, Gallo
Follow Cancer Chemotherapy and Pharmacology , Volume 68 (1)
Springer Journals – Jul 1, 2011reasons. They have a considerable cytotoxic activity against ovarian cancer and show favorable pharmacokinetics after IP administration: in addition, since they have a dose-dependent response, the high ...
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Sugar-labeled and PEGylated (bio)degradable polymers intended for targeted drug delivery systems
Freichels, H.; Jérôme, R.; Jérôme, C.
Follow Carbohydrate Polymers , Volume 86 (3)
Elsevier – Aug 30, 2011Highlights ► Controlled drug delivery systems are crucial to protect the drug and to allow it to reach the pathological area. ► Sugars as pilot molecules enable the targeting of tissues through sugar ...
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