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Methods for Analysis of Amyloid-β Aggregates
Bruggink, Kim A.; Müller, Mareike; Kuiperij, H. Bea; Verbeek, Marcel M.
Follow Journal of Alzheimer's Disease , Volume -1 (-1)
IOS Press – Jan 1, 2012Amyloid-β protein (Aβ) accumulation is one of the major hallmarks of Alzheimer's disease and plays a crucial role in its pathogenesis. Aβ aggregates into fibrils, but rather than these end-products ...
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Differential recognition of vascular and parenchymal beta amyloid deposition
Rutgers, Kim S.; van Remoortere, Alexandra; van Buchem, Mark A.; Verrips, C. Theo; Greenberg, Steven M.; Bacskai, Brian J.; Frosch, Matthew P.; van Duinen, Sjoerd G.; Maat-Schieman, Marion L.; van der Maarel, Silvère M.
Follow Neurobiology of Aging , Volume 32 (10)
Elsevier – Oct 1, 2011, immunohistochemistry and surface plasmon resonance. We identified eight distinct heavy chain antibody fragments specific for beta amyloid. While three of them recognized vascular and parenchymal beta amyloid deposits ...
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Novel phage peptides attenuate beta amyloid-42 catalysed hydrogen peroxide production and associated neurotoxicity
Taddei, K.; Laws, S.M.; Verdile, G.; Munns, S.; D’Costa, K.; Harvey, A.R.; Martins, I.J.; Hill, F.; Levy, E.; Shaw, J.E.; Martins, R.N.
Follow Neurobiology of Aging , Volume 31 (2)
Elsevier – Feb 1, 2010and extracellular deposits called amyloid plaques. A major protein component of the plaques is beta amyloid (Aβ), a 4 kDa spontaneously aggregating peptide of 39–43 amino acids ( Glenner and Wong, 1984; Masters et al ...
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Positron Emission Tomography Radiopharmaceuticals for Imaging Brain Beta-Amyloid
Vallabhajosula, Shankar
Follow Seminars in Nuclear Medicine , Volume 41 (4)
Elsevier – Jul 1, 2011of hyperphosphorylated tau protein. The amyloid is composed of 5 to 10 nm filaments of Aβ predominantly consisting of insoluble Aβ peptides, mostly 40 or 42 amino acids in length, with Aβ42 being the most prevalent ...
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Oxidation of methionine 35 reduces toxicity of the amyloid beta-peptide(1–42) in neuroblastoma cells (IMR-32) via enzyme methionine sulfoxide reductase A expression and function
Misiti, Francesco; Clementi, M. Elisabetta; Giardina, Bruno
Follow Neurochemistry International , Volume 56 (4)
Elsevier – Mar 1, 2010generally focus on the beta amyloid peptide (Aβ), a proteolytic product of 40–42 amino acids of the ubiquitously distributed amyloid precursor protein (APP), and its complexes of redox-active metal ions ...
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Monitoring the amyloid beta-peptide in vivo – caveat emptor
Thompson, Paul W.; Lockhart, Andrew
Follow Drug Discovery Today , Volume 14 (5)
Elsevier – Mar 1, 2009biomarkers. A relevant example of this is the extensive effort to characterise the Aβ42 assay developed by Innogenetics (INNOTEST beta-amyloid 1–42, antibody pair 3D6 (N-term 1–5) and 4D7A3 (C-term to 42)) [23 ...
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Inhibition of LTP in vivo by beta-amyloid peptide in different conformational states
Schmid, Adrien W.; Freir, Darragh B.; Herron, Caroline E.
Follow Brain Research , Volume 1197
Elsevier – Mar 4, 2008microscopy. We found distinctive changes in Aβ assembly demonstrating the formation of beta pleated sheets following 7-day incubation. Here we demonstrate that samples of the same Aβ1–40 peptide ...
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Protein aggregation as a paradigm of aging
Lindner, Ariel B.; Demarez, Alice
Follow Biochimica et Biophysica Acta (BBA) - General Subjects , Volume 1790 (10)
Elsevier – Oct 1, 2009[42–44] ( see below ). In contrast, much more is known about amyloid aggregation (appearing in forms of plaques or tangles) as they are is associated with numerous diseases, many of which are age ...
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Membrane cholesterol content plays a key role in the neurotoxicity of β‐amyloid: implications for Alzheimer’s disease
Abramov, Andrey Y.; Ionov, Maksim; Pavlov, Evgeny; Duchen, Michael R.
Follow Aging Cell , Volume 10 (4)
Wiley – Apr 11, 2011diagnosis of AD. Senile plaques are formed extracellularly and consist of insoluble aggregates of different isoforms (39–42 amino acids) of amyloid β (βA) peptide ( Masters , 1985 ; Haass & Selkoe, 2007 ...
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Failure of Aβ(1-40) amyloid fibrils under tensile loading
Paparcone, Raffaella; Buehler, Markus J.
Follow Biomaterials , Volume 32 (13)
Elsevier – May 1, 2011loading has not been elucidated yet, despite its importance for the understanding of key mechanical properties of amyloid fibrils and plaques as well as the growth and aggregation of amyloids into long ...
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