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    Development of rhizosecretion as a production system for recombinant proteins from hydroponic cultivated tobacco

    Drake, Pascal M. W.; Barbi, Tommaso; Sexton, Amy; McGowan, Edward; Stadlmann, Johannes; Navarre, Catherine; Paul, Matthew J.; Ma, Julian K.-C.
    Follow The FASEB Journal , Volume 23 (10): 3581
    Fed of American Socs for Experimental Biology – Oct 1, 2009

    ., Ma, J. K.-C. Development of rhizosecretion as a production system for recombinant proteins from hydroponic cultivated tobacco. Abstract Rhizosecretion is an attractive technology ...

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    More Like This 0G9RhKBj38 $4.99

    Rhizosecretion of recombinant proteins from plant hairy roots

    A., Gaume; S., Komarnytsky; N., Borisjuk; I., Raskin
    Follow Plant Cell Reports , Volume 21 (12)
    Springer Journals – Aug 1, 2003

    present in the plant at the time of extraction, which is lower than the integrated lifelong production. In order to overcome this problem, continuous, secretion-based plant systems have been developed ...

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    Rhizosecretion of a monoclonal antibody protein complex from transgenic tobacco roots

    Pascal, Drake; Daniel, Chargelegue; Nicholas, Vine; Craig, van Dolleweerd; Patricia, Obregon; Julian, Ma
    Follow Plant Molecular Biology , Volume 52 (1)
    Springer Journals – May 1, 2003

    weight per day. Rhizosecretion may be a viable alternative to agricultural production or cell culture for the generation of monoclonal antibodies in transgenic plants. It may also give rise to novel ...

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    Follow Human Antibodies , Volume 20 (3)
    IOS Press – Jan 1, 2011

    an inexpensive alternative to traditional systems for the production of recombinant monoclonal antibodies. However, cultivation of transgenic plants in the field raises regulatory concerns regarding product ...

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    Generation of transgenic plants expressing antibodies to the environmental pollutant microcystin-LR

    Drake, Pascal M. W.; Barbi, Tommaso; Drever, Matthew R.; van Dolleweerd, Craig J.; Porter, Andrew J. R.; Ma, Julian K.-C.
    Follow The FASEB Journal , Volume 24 (3): 882
    Fed of American Socs for Experimental Biology – Mar 1, 2010

    MC-LR compared to wild-type (WT) controls and that rhizosecreted antibody binds to MC-LR present in hydroponic medium. We suggest that transgenic plants may be a competitive production system ...

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    Production of antibodies in plants: status after twenty years

    De Muynck, Benoit; Navarre, Catherine; Boutry, Marc
    Follow Plant Biotechnology Journal , Volume 8 (5)
    Wiley – Feb 3, 2010

    production facilities, alternative expression systems have been developed, of which plants appear the most promising. In this review, we focus on the expression of monoclonal IgG or IgM in plant species. We ...

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    Alkylresorcinol Synthases Expressed in Sorghum bicolor Root Hairs Play an Essential Role in the Biosynthesis of the Allelopathic Benzoquinone Sorgoleone

    Cook, Daniel; Rimando, Agnes M.; Clemente, Thomas E.; Schröder, Joachim; Dayan, Franck E.; Nanayakkara, N.P. Dhammika; Pan, Zhiqiang; Noonan, Brice P.; Fishbein, Mark; Abe, Ikuro; Duke, Stephen O.; Baerson, Scott R.
    Follow The Plant Cell , Volume 22 (3): 867
    American Society of Plant Biologist – Jan 1, 2010

    and that the expected product, 5-pentadecatrienyl resorcinol, should also predominantly accumulate within this cell type. To explore this further, methanol extracts prepared from root hairs, root systems, developing ...

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    Transgenic plant production of Cyanovirin-N, an HIV microbicide

    Sexton, Amy; Drake, Pascal M.; Mahmood, Naheed; Harman, Sarah J.; Shattock, Robin J.; Ma, Julian K-C.
    Follow The FASEB Journal , Volume 20 (2): 356
    Fed of American Socs for Experimental Biology – Feb 1, 2006

    of aggregation associated with Escherichia coli production of CV-N. PRINCIPAL FINDINGS 1. Transgenic tobacco plants expressing recombinant CV-N were generated rCV-N was recovered from ...

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    Production of Recombinant Proteins in Tobacco Guttation Fluid

    Komarnytsky, Slavko; Borisjuk, Nikolai V.; Borisjuk, Ljudmila G.; Alam, Muhammad Z.; Raskin, Ilya
    Follow Plant Physiology , Volume 124 (3): 927
    American Society of Plant Biologist – Nov 1, 2000

    ). However, in vitro systems can be expensive, slow growing, unstable, and relatively low yielding. To partially overcome this problem, a rhizosecretion system for the production of recombinant proteins has ...

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    Cosecretion of Protease Inhibitor Stabilizes Antibodies Produced by Plant Roots

    Komarnytsky, Slavko; Borisjuk, Nikolai; Yakoby, Nir; Garvey, Alison; Raskin, Ilya
    Follow Plant Physiology , Volume 141 (4): 1185
    American Society of Plant Biologist – Aug 1, 2006

    >A plant-based system for continuous production of monoclonal antibodies based on the secretion of immunoglobulin complexes from plant roots into a hydroponic medium (rhizosecretion) was engineered ...

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