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for: dendritic cells differentiated in the presence of ifn beta and il 3
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IL-10-conditioned dendritic cells prevent autoimmune diabetes in NOD and humanized HLA-DQ8/RIP-B7.1 mice
Tai, Ningwen; Yasuda, Hisafumi; Xiang, Yufei; Zhang, Li; Rodriguez-Pinto, Daniel; Yokono, Koichi; Sherwin, Robert; Wong, F. Susan; Nagata, Masao; Wen, Li
Follow Clinical Immunology , Volume 139 (3)
Elsevier – Jun 1, 2011This study was to determine whether BMDCs cultured in the presence of IL-10 (G/10-DCs) could promote T cell tolerance and prevent autoimmune diabetes in two different animal models of T1D. Our ...
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Regulation of angiostatic chemokines driven by IL-12 and IL-27 in human tumors
Airoldi, Irma; Ribatti, Domenico
Follow Journal of Leukocyte Biology , Volume 90 (5): 875
Fed of American Socs for Experimental Biology – Nov 1, 2011growth factor-2 HIF-1α hypoxia-inducible factor 1 α IFN interferon IL interleukin MM multiple myeloma NSCLC non-small cell lung cancer PROK-2 prokinecitin-2 SCCA squamous cell carcinoma TGF-β transforming ...
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Analysis of the cumulative changes in Graves’ disease thyroid glands points to IFN signature, plasmacytoid DCs and alternatively activated macrophages as chronicity determining factors
Ruiz-Riol, Marta; Armengol Barnils, Maria del Pilar; Colobran Oriol, Roger; Sánchez Pla, Alex; Borràs Serres, Francesc-E.; Lucas-Martin, Anna; Martínez Cáceres, Eva María; Pujol-Borrell, Ricardo
Follow Journal of Autoimmunity , Volume 36 (3)
Elsevier – May 1, 2011“communication between innate and adaptive immune cells” and “autoimmune thyroid signaling”. A broad IFN signature consisted of the over-expression of 74 and 84 type I and type II IFN responsive genes respectively ...
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Tissue-targeted therapy of autoimmune diabetes using dendritic cells transduced to express IL-4 in NOD mice
Creusot, Rémi J.; Yaghoubi, Shahriar S.; Kodama, Keiichi; Dang, Demi N.; Dang, Vu H.; Breckpot, Karine; Thielemans, Kris; Gambhir, Sanjiv S.; Fathman, C. Garrison
Follow Clinical Immunology , Volume 127 (2)
Elsevier – May 1, 2008vectors [25] , prevented T1D when NOD mice were treated at a young age (up to 7 weeks). At the level of cellular gene therapy, IL-4-expressing transduced T cells [26,27] or dendritic cells (DCs) [28] have ...
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A tolerogenic peptide that induces suppressor of cytokine signaling (SOCS)-1 restores the aberrant control of IFN-γ signaling in lupus-affected (NZB × NZW)F1 mice
Sharabi, Amir; Sthoeger, Zev M.; Mahlab, Keren; Lapter, Smadar; Zinger, Heidy; Mozes, Edna
Follow Clinical Immunology , Volume 133 (1)
Elsevier – Oct 1, 2009the expression of these two molecules in association with clinical amelioration. In vitro stimulation with IFN-γ resulted in elevated levels of SOCS-1 in cells from both vehicle and hCDR1-treated mice ...
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Effects of bacterial products on enterocyte–macrophage interactions in vitro
Tyrer, Peter C.; Bean, Elaine G.; Ruth Foxwell, A.; Pavli, Paul
Follow Biochemical and Biophysical Research Communications , Volume 413 (2)
Elsevier – Sep 23, 2011Highlights ► Human blood monocytes cocultured with Caco-2 cells develop intestinal macrophage phenotype. ► LPS and MDP induce monocyte migration into cultures. ► LPS and MDP differentially affect ...
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Conjugated linoleic acid and inflammatory cell signalling
Reynolds, C.M.; Roche, H.M.
Follow Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) , Volume 82 (4)
Elsevier – Apr 1, 2010to form IL-23, a cytokine involved in differentiation of Th17 cells. IL-12 promotes differentiation of naïve Th cells to Th1 cells which produce interferon gamma (IFN-γ), tumor necrosis factor beta (TNF-β ...
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Autoimmune and inflammatory mechanisms of CNS damage
Kapadia, Minesh; Sakic, Boris
Follow Progress in Neurobiology , Volume 95 (3)
Elsevier – Nov 1, 2011responses in the CNS were largely attributed to the T h 1 lymphocyte subclass which requires the cytokine interleukin (IL)-12 for differentiation and secretes interferon (IFN)-gamma, IL-2 and tumor necrosis ...
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Renal tubular epithelial cells as immunoregulatory cells in renal allograft rejection
Nguan, Christopher Y.C.; Du, Caigan
Follow Transplantation Review , Volume 23 (3)
Elsevier – Jul 1, 2009during acute rejection [13] , and these monocytes including dendritic cells produce abundant IL-1 upon interaction with sensitized antigen-specific T cells [14] , suggesting that IL-1 produced ...
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Mammalian target of rapamycin (mTOR) regulates TLR3 induced cytokines in human oral keratinocytes
Zhao, Jiawei; Benakanakere, Manjunatha R.; Hosur, Kavita B.; Galicia, Johnah C.; Martin, Michael; Kinane, Denis F.
Follow Molecular Immunology , Volume 48 (1)
Elsevier – Nov 1, 2010-myeloid cells such as human keratinocytes is unknown. Here we show that TLR3 signaling can induce robust cytokine secretion including interleukin 1 beta (IL-1β), tumor necrosis factor alpha (TNFα), IL-12p70 ...
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