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for: conformational signals in the c terminal domain of methionine
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Conformational signals in the C-terminal domain of methionine adenosyltransferase I/III determine its nucleocytoplasmic distribution
Reytor, Edel; Pérez-Miguelsanz, Juliana; Alvarez, Luis; Pérez-Sala, Dolores; Pajares, María A.
Follow The FASEB Journal , Volume 23 (10): 3347
Fed of American Socs for Experimental Biology – Oct 1, 2009. A. Conformational signals in the C-terminal domain of methionine adenosyltransferase I/III determine its nucleocytoplasmic distribution. Abstract The methyl donor S -adenosylmethionine is synthesized ...
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Conformational capture of the SAM-II riboswitch
Haller, Andrea; Rieder, Ulrike; Aigner, Michaela; Blanchard, Scott C; Micura, Ronald
Follow Nature Chemical Biology , Volume 7 (6)
Nature Publishing Group (NPG) – May 1, 2011–competent conformations. However, to avoid spurious signaling, such states must necessarily be highly unstable to ensure that the default folding pathway predominates in the absence of ligand.In recent ...
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Structural Characterization of the Natively Unfolded N-Terminal Domain of Human c-Src Kinase: Insights into the Role of Phosphorylation of the Unique Domain
Pérez, Yolanda; Gairí, Margarida; Pons, Miquel; Bernadó, Pau
Follow Journal of Molecular Biology , Volume 391 (1)
Elsevier – Aug 7, 2009: SH4, unique domain, SH3, SH2, kinase (catalytic), and the C-terminal regulatory region. The sequence homology within the family is rather high with the exception of the N-terminal region comprising ...
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Tuning Riboswitch Regulation through Conformational Selection
Wilson, Ross C.; Smith, Angela M.; Fuchs, Ryan T.; Kleckner, Ian R.; Henkin, Tina M.; Foster, Mark P.
Follow Journal of Molecular Biology , Volume 405 (4)
Elsevier – Jan 28, 2011riboswitch mechanisms involve regulation at the level of premature termination of transcription or translation initiation. Riboswitches that affect transcription termination undergo a conformational switch ...
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The structural intolerance of the PrP α-fold for polar substitution of the helix-3 methionines
Silvia, Lisa; Massimiliano, Meli; Gema, Cabello; Ruth, Gabizon; Giorgio, Colombo; María, Gasset
Follow Cellular and Molecular Life Sciences , Volume 67 (16)
Springer Journals – Aug 1, 2010and the accumulation of sulfoxidized methionines. Computational and synthetic approaches have shown that this change in the polarity of M206 and M213 impacts the C-terminal domain native α-fold allowing the flexibility ...
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cGMP-binding Prepares PKG for Substrate Binding by Disclosing the C-terminal Domain
Alverdi, Vera; Mazon, Hortense; Versluis, Cees; Hemrika, Wieger; Esposito, Gennaro; van den Heuvel, Robert; Scholten, Arjen; Heck, Albert J.R.
Follow Journal of Molecular Biology , Volume 375 (5)
Elsevier – Feb 1, 2008the amino-terminal site with the two in-tandem cGMP-binding pockets. The C-terminal part of the protein harbors the catalytic domain, which consists of a MgATP-binding pocket and the substrate-binding site. ...
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Inherent flexibility and protein function: The open/closed conformational transition in the N-terminal domain of calmodulin
Tripathi, Swarnendu
Follow The Journal of Chemical Physics , Volume 128 (20)
American Institute of Physics – May 28, 2008conformational substrates of the C-terminal domain of calmodulin (cCaM) by NMR N 15 spin relaxation experiments. A comparison of exchange rates as a function of Ca 2+ Ca 2 + concentration has established ...
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GRAS proteins: the versatile roles of intrinsically disordered proteins in plant signalling
Xiaolin Sun* 1 , William T. Jones* and Erik H. A. Rikkerink†
Follow Biochemical Journal , Volume 442 (1)
Portland Press – Feb 15, 2012and diverse roles in plant development and signalling, and act as integrators of signals from multiple plant growth regulatory and environmental inputs. Possessing an intrinsically disordered N-terminal domain ...
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The regulation of TNF signalling: what a tangled web we weave
Silke, John
Follow Current Opinion in Immunology , Volume 23 (5)
Elsevier – Oct 1, 2011it deviates from this simple picture and also because the existence and importance of it has only recently been appreciated [ 7 ]. The amino terminal NH 2 of the initiator Methionine provides a potential ...
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Identification of an Allosteric Signaling Network within Tec Family Kinases
Joseph, Raji E.; Xie, Qian; Andreotti, Amy H.
Follow Journal of Molecular Biology , Volume 403 (2)
Elsevier – Oct 22, 2010the N- and C-terminal lobes of the kinase domain. Assembly of the regulatory spine has been proposed to be a crucial step in the activation of protein kinases, and this structure is disrupted ...
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