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Resurgent study of trauma-induced coagulopathy (TIC) has delivered considerable improvements in survival after injury. Robust, valid and clinically relevant experimental models of TIC are essential ...
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synthesis, thus suggesting a close relationship between synthesis and metabolism of cholesterol in the brain. The other mechanism of cholesterol elimination, called reverse cholesterol transport pathway ...
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transection injury, hypoglycemia, and metabolic impairment with 3-nitropropionic acid (14); MK-801 also reduced LDH release and trypan blue uptake after combined biaxial stretch and hypoxia (66). After moderate ...
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phytochemicals of red and white ginger on acetylcholinesterase activities, and sodium nitroprusside (SNP) and quinolinic acid (QA)-induced lipid peroxidation in rat brain – in vitro . Both extracts inhibited ...
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mechanisms involved in the metabolite-mediated neuronal damage: excitotoxicity, impairment of energy metabolism and oxidative stress. There is evidence that during a metabolic crisis GA and its metabolites ...
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in response to mechanical stimulation [8]. Besides in vitro studies, in vivo studies showed a proosteogenic function for the P2X7R on bone metabolism. It was shown that mice lacking the P2X7R had significantly ...
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of Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), Huntington’s disease (HD), stroke, and brain trauma. Therapeutic trials with melatonin indicate that it has a potential ...
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cerebral energy metabolism contribute to the brain cell death that is responsible for much of the poor neurologic outcome from these events. Recent results obtained from both in vitro and animal models ...
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have evidenced that some metal ions induce microglial activation which may be involved in neurodegenerative diseases. Zinc (II) [4] , cadmium (II) [5] and manganese (II) [6–8] alone or combined with LPS ...