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protein acylation is an enzymatic process, but also cellular protein deacylation, a process catalyzed by enzymes that remove the acyl moiety. Although some deacylases might remain to be discovered ...
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, it is recognized that trafficking to these novel destinations involves new biochemical mechanisms, such as proteolytic processing or interaction with translocons, and that these trafficking events have a function ...
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been associated with a wide range of pathological processes, being receptors for viruses (i.e., simian virus 40, SV40), toxins [i.e., cholera (CTx); tetanus and botulinus toxins], lectins and antibodies ...
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), deactivation (PTEN-mediated) and receptor trafficking/signalling (Rab5-mediated) functions, all with key roles in maintaining cellular homoeostasis.Key words: actin reorganization, phosphatase and tensin ...
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will outline the early studies on LDL and transferrin receptors and will then focus on two classes of signaling receptors, receptor tyrosine kinases (EGF and the insulin receptors) and heterotrimeric G-protein ...
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cells by amyloid‐β42 (Aβ)‐induced toxicity. Aβ affects both activation of insulin receptors and the levels of phospho‐Akt, a critical signalling molecule in this pathway. In contrast, oxidative stress ...
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: Insulin; immature secretory granule; trans-Golgi network; endosomal system; lysosomal enzymes; multimerization; endoproteolytic processing; yeast vps mutants; -1 antitrypsin. INTRODUCTION Over the past 10 ...
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trafficking from the endoplasmic reticulum. Therefore, our data suggest that palmitoylation plays a critical role in ABCG1-mediated cholesterol efflux through the regulation of trafficking. 1 Introduction ...
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Background Investigation of the molecular processes that control the development and function of lymphocytes is essential for our understanding of humoral immunity, as well as lymphocyte‐associated ...