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, and cells of lower eukaryotes, e.g., yeasts, contain additional Ca 2+ pumps. They have interesting properties, but are not discussed in this review, as its focus is on the disease processes linked ...
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="Endolysosomal calcium regulation and disease" AuthorText="Emyr Lloyd-Evans* 1 , Helen Waller-Evans†, Ksenia Peterneva* and Frances M. Platt*" Affiliation="*Department of Pharmacology, University of Oxford ...
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and promotes resorption of bone by osteoclasts to mobilize bone calcium ( Fig. 1 ) . To demineralize bone, osteoclasts secrete hydrochloric acid using a proton pump and a chloride channel, releasing calcium ...
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regulatory mechanisms, and its significance in human health and diseases (e.g., Refs. [15,32,34–36,53–64] ). For example, ouabain can stimulate protein kinase cascades and regulate cell growth in cardiac ...
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calcium patterns in response to electrical excitation. The lack of T-tubules in atrial myocytes means that depolarisation provokes calcium signals that originate around the periphery of the cells. Under ...
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). Calcium is known to function as a second messenger in response to intracellular and extracellular stimuli and also mediates various physiological actions through calcium channels and pumps. ...
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at centre stage for regulating intracellular Ca 2+ signalling and homoeostasis in health and disease.Discovery of the lysosomeThe lysosome is a highly specialized acidic intracellular organelle ...
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proton pump inhibitors, antacids, or medication known to interfere with calcium absorption such as steroids, anticonvulsants, or antibiotics. We also excluded women taking medications known to interact ...
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we discuss DD from the viewpoint of Ca2+ signaling and present a potential role for TRPC1 in the disease pathogenesis. Keywords. Darier#29;s disease, SERCA, calcium signaling, SOCE, TRPC channel, cell ...
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which students can begin to think about whole organ physiology in health and disease. Greater synchrony of Ca 2+ -regulatory mechanisms between ventricular and pacemaker cells should enhance student ...
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