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The functional coupling of T cell receptor (TCR)-mediated signaling events in primary human T cells remains undefined. We demonstrate here that alterations in the expression of proximal TCR-coupled ...
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clones are reported to have multiple alterations in TCR-associated signalling ( Gajewski et al., 1994 ). In vivo anergised CD4 + T-cell clones show perturbed binding affinity for transcription factors ...
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of intracellular signaling following activation of T lymphocytes through engagement of the T cell receptor (TCR)/CD3 complex. Molecules whose mutations have been associated with immunodeï¬ciency in humans ...
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of the high affinity receptor for IgE). Although the majority of adult thymocytes and peripheral T cells express TCRs associated with t homodimers, each of the t-family proteins can function as a signal ...
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the peripheral T cells expressed similar amounts of Foxo1 ( Fig. 1a ). Foxo1 resides in the nucleus of quiescent T cells, and relocates to the cytosol after T-cell receptor (TCR) stimulation. To investigate ...
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of this chain [1–3] . It was subsequently determined that the heavy-chain gene of the BCR and the T-cell receptor (TCR) genes were rearranged by a similar recombination process (reviewed in Refs. [4, 5 ...
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are activated by two signals: Signal One is contact of the T cell antigen receptor (TCR) with antigenic peptide complexed to MHC molecules on the surface of antigen-presenting cells (APC), and Signal Two ...
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in Jurkat and Hut 78 T cells, as well as primary human peripheral blood and intrahepatic mononuclear cells. HCVne uptake leads to activation of the MAPKs-p38 signaling pathway. Using specific ...
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in about 6â12 h by delivery of a strong T cell receptor (TCR) signal in the absence of costimulation or by stimulation with a low-afï¬nity ligand in the presence of costimulation. It was recently ...