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for: age associated changes of extracellular matrix collagen impair lung
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Age-associated changes of extracellular matrix collagen impair lung cancer cell migration
Bartling, Babett; Desole, Maximilian; Rohrbach, Susanne; Silber, Rolf-Edgar; Simm, Andreas
Follow The FASEB Journal , Volume 23 (5): 1510
Fed of American Socs for Experimental Biology – May 1, 2009, B., Desole, M., Rohrbach, S., Silber, R.-E., Simm, A. Age-associated changes of extracellular matrix collagen impair lung cancer cell migration. Abstract Although advanced age is linked ...
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Spaceflight modulates expression of extracellular matrix, adhesion, and profibrotic molecules in mouse lung
Tian, Jian; Pecaut, Michael J.; Slater, James M.; Gridley, Daila S.
Follow Journal of Applied Physiology , Volume 108 (1): 162
The American Physiological Society – Jan 1, 2010of spaceflight on expression of extracellular matrix (ECM), cell adhesion, and pro-fibrotic molecules in lungs of mice flown on Space Shuttle Endeavour (STS-118). C57BL/6Ntac mice housed in animal enclosure ...
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SPARC mediates early extracellular matrix remodeling following myocardial infarction
McCurdy, Sarah M.; Dai, Qiuxia; Zhang, Jianhua; Zamilpa, Rogelio; Ramirez, Trevi A.; Dayah, Tariq; Nguyen, Nguyen; Jin, Yu-Fang; Bradshaw, Amy D.; Lindsey, Merry L.
Follow AJP - Heart and Circulatory Physiology , Volume 301 (2): H497
The American Physiological Society – Aug 1, 2011Abstract Secreted protein, acidic, and rich in cysteine (SPARC) is a matricellular protein that functions in the extracellular processing of newly synthesized collagen. Collagen deposition to form ...
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Aberrant signaling pathways of the lung mesenchyme and their contributions to the pathogenesis of bronchopulmonary dysplasia
Ahlfeld, Shawn K.; Conway, Simon J.
Follow Birth Defects Research Part A , Volume 94 (1)
Wiley – Nov 28, 2011>Pathologic Changes in Lung Mesenchyme and Development Associated with BPD A limited number of autopsy samples from infants with gestational ages younger than 30 weeks in the presurfactant ...
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Bronchoalveolar matrix metalloproteinase 9 relates to restrictive lung function impairment in systemic sclerosis
Andersen, Grethe Neumann; Nilsson, Kenneth; Pourazar, Jamshid; Hackett, Tillie-Louise; Kazzam, Elsadig; Blomberg, Anders; Waldenström, Anders; Warner, Jane; Rantapää-Dahlqvist, Solbritt; Mincheva-Nilsson, Lucia; Sandström, Thomas
Follow Respiratory Medicine , Volume 101 (10)
Elsevier – Oct 1, 2007Systemic sclerosis (SSc) is frequently associated with interstitial lung disease (ILD) often leading to lung fibrosis. In this study we investigated whether matrix metalloproteinase 9 (MMP-9) and its ...
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Severe lung fibrosis requires an invasive fibroblast phenotype regulated by hyaluronan and CD44
Li, Yuejuan; Jiang, Dianhua; Liang, Jiurong; Meltzer, Eric B.; Gray, Alice; Miura, Riu; Wogensen, Lise; Yamaguchi, Yu; Noble, Paul W.
Follow The Journal of Experimental Medicine , Volume 208 (7): 1459
Rockefeller University Press – Jul 4, 2011progressive fibrosis are unknown. Myofibroblasts accumulate at sites of tissue remodeling and produce extracellular matrix components such as collagen and hyaluronan (HA) that ultimately compromise organ ...
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Prevention of Ischemia/Reperfusion-Induced Accumulation of Matrix Metalloproteinases in Rat Lung by Preconditioning With Nitric Oxide
Waldow, Thomas; Witt, Wolfgang; Buzin, Anne; Ulmer, André; Matschke, Klaus
Follow Journal of Surgical Research , Volume 152 (2)
Elsevier – Apr 1, 2009. The integrity of the lung permeability barrier relies on intact endothelial cell–cell interactions and the adhesion to the extracellular matrix (ECM). Barrier function can be compromised by enzymatic degradation ...
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Matrix Metalloproteinases in Lung: Multiple, Multifarious, and Multifaceted
Greenlee, Kendra J.; Werb, Zena; Kheradmand, Farrah
Follow Physiological Reviews , Volume 87 (1): 69
The American Physiological Society – Jan 1, 2007of these diseases. Furthermore, potential MMP targets in the lung include all structural proteins in the extracellular matrix (ECM), cell adhesion molecules, growth factors, cytokines, and chemokines. However, what ...
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Fatty diabetic lung: altered alveolar structure and surfactant protein expression
Foster, David J.; Ravikumar, Priya; Bellotto, Dennis J.; Unger, Roger H.; Hsia, Connie C. W.
Follow AJP - Lung Cellular and Molecular Physiology , Volume 298 (3): L392
The American Physiological Society – Mar 1, 2010expression declined with age. Thus lungs from obese T2DM animals develop many qualitatively similar changes as in type 1 diabetes mellitus but with extensive lipid deposition, altered alveolar type 2 cell ...
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Aging and lung injury repair: A role for bone marrow derived mesenchymal stem cells
Mora, Ana L.; Rojas, Mauricio
Follow Journal of Cellular Biochemistry , Volume 105 (3)
Wiley – Sep 26, 2008The incidence of lung fibrosis increases with age. Aging is associated with modifications in the intracellular and extracellular environment including alteration of the extracellular matrix ...
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