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ABC drug transporters and immunity: novel therapeutic targets in autoimmunity and cancer
van de Ven, Rieneke; Oerlemans, Ruud; van der Heijden, Joost W.; Scheffer, George L.; de Gruijl, Tanja D.; Jansen, Gerrit; Scheper, Rik J.
Follow Journal of Leukocyte Biology , Volume 86 (5): 1075
Fed of American Socs for Experimental Biology – Nov 1, 2009. The relevance of ABC transporters for immune functions raises the issue immediately of how the combined administration of therapeutic drugs and ABC transporter antagonists would influence the survival ...
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Macrophages: An elusive yet emerging therapeutic target of atherosclerosis
Tiwari, R.L.; Singh, V.; Barthwal, M.K.
Follow Medicinal Research Reviews , Volume 28 (4)
Wiley – Apr 24, 2008in this phenomenon. Proteins affecting macrophage cholesterol metabolism and transport, including ATP‐binding cassette (ABC) A1, ABCG1, acyl‐CoA:cholesterol acyltransferase (ACAT), apolipoprotein A‐1 (ApoA‐1), neutral ...
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Increased expression of cdc2 inhibits transport function of RLIP76 and promotes apoptosis
Singhal, Sharad S.; Yadav, Sushma; Vatsyayan, Rit; Chaudhary, Pankaj; Borvak, Jozef; Singhal, Jyotsana; Awasthi, Sanjay
Follow Cancer Letters , Volume 283 (2)
Elsevier – Oct 8, 2009clinical data indicate that the ABC-transporters P-glycoprotein (Pgp), MRP1 and related transporters are clearly able to mediate drug-accumulation defects in cultured malignant cells, but correlations ...
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Mining quorum sensing regulated proteins – Role of bacterial cell‐to‐cell communication in global gene regulation as assessed by proteomics
Hecker, Michael
Follow PROTEOMICS , Volume 11 (15)
Wiley – May 5, 2011of pathogenic traits and biofilm formation in various opportunistic pathogens, it represents a highly attractive target for the development of novel antibacterial drugs. Proteomics has also been exploited ...
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Quinoline antimalarials as investigational drugs for HIV‐1/AIDS: in vitro effects on HIV‐1 replication, HIV‐1 response to antiretroviral drugs, and intracellular antiretroviral drug concentrations
Savarino, Andrea; Lucia, Mothanje B.; ter Heine, Rob; Rastrelli, Elena; Rutella, Sergio; Majori, Giancarlo; Huitema, Alwin; Boelaert, Johan R.; Cauda, Roberto
Follow Drug Development Research , Volume 67 (10)
Wiley – Jan 10, 2007concentrations were quantitated by HPLC. Results indicated that: (1) the antimalarials (mefloquine > chloroquine) inhibited the replication of drug‐sensitive and drug‐resistant HIV‐1 at therapeutically achievable ...
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A nuclear receptor-like pathway regulating multidrug resistance in fungi
Thakur, Jitendra K.; Arthanari, Haribabu; Yang, Fajun; Pan, Shih-Jung; Fan, Xiaochun; Breger, Julia; Frueh, Dominique P.; Gulshan, Kailash; Li, Darrick K.; Mylonakis, Eleftherios; Struhl, Kevin; Moye-Rowley, W. Scott; Cormack, Brendan P.; Wagner, Gerhard; Näär, Anders M.
Follow Nature , Volume 452 (7187)
Nature Publishing Group (NPG) – Apr 3, 2008in antifungal/xenobiotic-dependent regulation of MDR. This detailed mechanistic understanding of a fungal nuclear receptor-like gene regulatory pathway provides novel therapeutic targets for the treatment ...
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Abstracts: Turkish Society of Molecular Medicine, Third International Congress of Molecular Medicine, May 5–8, 2009, Istanbul, Turkey
Isbir, Turgay
Follow IUBMB Life , Volume 61 (3)
Wiley – Feb 25, 2009and genetic. The responsible genes are thought to be the ones expressing drug‐metabolising enzymes such as cytochrome p450, drug‐transporting proteins as p‐glycoproteins and/or the drug targets such as receptor ...
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Preclinical pharmacokinetics and bioavailability of noscapine, a tubulin-binding anticancer agent
Ritu, Aneja; Neerupma, Dhiman; Jyoti, Idnani; Anshumali, Awasthi; Sudershan, Arora; Ramesh, Chandra; Harish, Joshi
Follow Cancer Chemotherapy and Pharmacology , Volume 60 (6)
Springer Journals – Nov 1, 2007in modulating the oral bioavailability and pharmacokinetics of drugs [18, 19]. Given that other microtubule drugs are better substrates for various ABC transporters that can alter drug distribution due ...
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Abstract for the 8th International congress, Molecular Epidemiology and Evolutionary Genetics of Infectious Diseases
Follow Infection, Genetics and Evolution , Volume 8 (4)
Elsevier – Jul 1, 2008of the antiretrovirals are metabolized by polymorphically expressed enzymes (cytochrome P450, CYP450; glucuronyl transferase, GT) and/or transported by drug transporters (ABC and SLC families). The nonnucleoside reverse ...
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BIOSPINE 2: 2nd International Congress, Biotechnologies for Spinal Surgery, Leipzig, Germany, 20–22 September, 2007
Follow European Spine Journal , Volume 16 (10)
Springer Journals – Oct 1, 2007these new therapeutic approaches have the potential to bring novel products based on nanostructured materials for cell-based therapy of spinal cord injury and stroke into the clinic. Stroke is the third ...
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