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by diet, exercise and lifestyle changes, albeit ineffectually for most in the long term ( Wu et al., 2009 ), a high degree of safety is required of anti-obesity treatments. The FDA therefore requires ...
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with increasing gastric distention. The secretion of acid is regulated by various physiological signals36,37 to avoid excessive acidification of the stomach. These events define the gastric phase of stomach ...
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administration can predict the later development of obesity in rodents on a high-energy diet ( 244 ). Furthermore, a high-fat diet itself, before changes in body composition, may induce leptin resistance, since ...
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meal may take even more than 4 hours. Several hormones modulate the motor and digestive process, including gastrin (eg, through acid secretion), CCK (eg, gallbladder contraction, bile and pancreatic ...
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fatty acids 25 increase intestinal proglucagon mRNA levels. Gastrin-releasing peptide (GRP) and GIP increase intestinal proglucagon mRNA levels in mouse enteroendocrine cells and primary fetal rat ...
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of the tissues of the body. Charged with the formidable task of regulating nutrient homeostasis are the islets of Langerhans, microorgans that perform these functions through the secre� tion of three or more ...
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bile acid secretion. We therefore investigated whether Fabp1 participates in the regulation of bile acid synthesis. Male wild type (wt) and Fabp1 -/- mice were either fed a cholic acid (CA; 0.5% w/w ...
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. Previous studies have shown that, in contrast to wild-type mice, GIP receptor-deficient mice develop neither insulin resistance nor obesity while consuming a high-fat diet. Studies in adipocytes from our ...
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processed forms of gastrin can modulate colonic proliferation and intestinal tumorigenesis in the mouse. In addition, incompletely processed gastrins have been shown to modulate acid secretion and histologic ...