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- Publisher
- Wiley
- Copyright
- Copyright © 2001 John Wiley & Sons, Inc.
- ISSN
- 0006-3525
- eISSN
- 1097-0282
- DOI
- 10.1002/1097-0282(2000)55:4<254::AID-BIP1001>3.3.CO;2-T
- Publisher site
- See Article on Publisher Site
Abstract
Interferon (IFN) was approved by the U.S. Food and Drug Administration on June 5, 1986. As the first biotherapeutic approved, IFN‐α paved the way for development of many other cytokines and growth factors. Nevertheless, we have just touched the surface of understanding the multitude of human IFNs. This paper reviews the history of the purification of human leukocyte IFN and key aspects of our current state of knowledge of human interferon α genes, proteins, and receptors. © 2001 John Wiley & Sons, Inc. Biopolymers (Pept Sci) 55: 254–287, 2000
Journal
Biopolymers – Wiley
Published: Jan 1, 2000
Keywords: interferon; biotherapeutic; cytokines; growth factors; human leucocyte; genes; proteins; receptors