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The carbonate radical and related oxidants derived from bicarbonate buffer

The carbonate radical and related oxidants derived from bicarbonate buffer The unequivocal demonstration that the carbonate radical (CO3 •‐) is produced from the reaction between the ubiquitous carbon dioxide and peroxynitrite, renewed the interest in the pathogenic roles of oxidants derived from the main physiological buffer, the bicarbonate‐carbon dioxide pair. Here, we review the biochemical properties of both the carbonate radical and peroxymonocarbonate (HCO4 ‐), and discuss the evidence of their formation under physiological conditions. Overall, the review emphasizes the recognition of the biological relevance of oxidants derived from the main physiological buffer as a crucial step into the understanding and control of numerous pathological states. IUBMB Life, 59: 1 ‐ 8, 2007 IUBMB Life, 59: 255‐262, 2007 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png IUBMB Life Wiley

The carbonate radical and related oxidants derived from bicarbonate buffer

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References (56)

Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
Copyright © 2007 International Union of Biochemistry and Molecular Biology
ISSN
1521-6543
eISSN
1521-6551
DOI
10.1080/15216540701230511
pmid
17505962
Publisher site
See Article on Publisher Site

Abstract

The unequivocal demonstration that the carbonate radical (CO3 •‐) is produced from the reaction between the ubiquitous carbon dioxide and peroxynitrite, renewed the interest in the pathogenic roles of oxidants derived from the main physiological buffer, the bicarbonate‐carbon dioxide pair. Here, we review the biochemical properties of both the carbonate radical and peroxymonocarbonate (HCO4 ‐), and discuss the evidence of their formation under physiological conditions. Overall, the review emphasizes the recognition of the biological relevance of oxidants derived from the main physiological buffer as a crucial step into the understanding and control of numerous pathological states. IUBMB Life, 59: 1 ‐ 8, 2007 IUBMB Life, 59: 255‐262, 2007

Journal

IUBMB LifeWiley

Published: Jan 1, 2007

Keywords: Carbonate radical; oxidants; bicarbonate buffer

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