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Stress, social rank and leukocyte telomere length

Stress, social rank and leukocyte telomere length Summary Blood leukocytes are a heterogeneous mixture of cell types whose telomere lengths differ greatly, reflecting variation in stem cell turnover and recruitment, expansion and replacement of more mature cell types as well as variable telomere loss and telomere repair. These differences in cell and telomere length dynamics, together with the evidence that telomere length is influenced strongly by genetic polymorphisms, greatly complicate the interpretation of claims that socio-economic status modulates the rate of telomere attrition. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Aging Cell Wiley

Stress, social rank and leukocyte telomere length

Aging Cell , Volume 5 (6) – Dec 1, 2006
2 pages

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References (9)

Publisher
Wiley
Copyright
© 2006 The Author Journal compilation © Blackwell Publishing Ltd/Anatomical Society of Great Britain and Ireland 2006
ISSN
1474-9718
DOI
10.1111/j.1474-9726.2006.00247.x
pmid
17081156
Publisher site
See Article on Publisher Site

Abstract

Summary Blood leukocytes are a heterogeneous mixture of cell types whose telomere lengths differ greatly, reflecting variation in stem cell turnover and recruitment, expansion and replacement of more mature cell types as well as variable telomere loss and telomere repair. These differences in cell and telomere length dynamics, together with the evidence that telomere length is influenced strongly by genetic polymorphisms, greatly complicate the interpretation of claims that socio-economic status modulates the rate of telomere attrition.

Journal

Aging CellWiley

Published: Dec 1, 2006

Keywords: stem cells; leukocyte subsets; telomerase; telomeres

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