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SIRT1 transgenic mice show phenotypes resembling calorie restriction

SIRT1 transgenic mice show phenotypes resembling calorie restriction Summary We generated mice that overexpress the sirtuin, SIRT1. Transgenic mice have been generated by knocking in SIRT1 cDNA into the ॆ-actin locus. Mice that are hemizygous for this transgene express normal levels of ॆ-actin and higher levels of SIRT1 protein in several tissues. Transgenic mice display some phenotypes similar to mice on a calorie-restricted diet: they are leaner than littermate controls; are more metabolically active; display reductions in blood cholesterol, adipokines, insulin and fasted glucose; and are more glucose tolerant. Furthermore, transgenic mice perform better on a rotarod challenge and also show a delay in reproduction. Our findings suggest that increased expression of SIRT1 in mice elicits beneficial phenotypes that may be relevant to human health and longevity. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Aging Cell Wiley

SIRT1 transgenic mice show phenotypes resembling calorie restriction

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References (27)

Publisher
Wiley
Copyright
© 2007 The Authors Journal compilation © Blackwell Publishing Ltd/Anatomical Society of Great Britain and Ireland 2007
ISSN
1474-9718
DOI
10.1111/j.1474-9726.2007.00335.x
pmid
17877786
Publisher site
See Article on Publisher Site

Abstract

Summary We generated mice that overexpress the sirtuin, SIRT1. Transgenic mice have been generated by knocking in SIRT1 cDNA into the ॆ-actin locus. Mice that are hemizygous for this transgene express normal levels of ॆ-actin and higher levels of SIRT1 protein in several tissues. Transgenic mice display some phenotypes similar to mice on a calorie-restricted diet: they are leaner than littermate controls; are more metabolically active; display reductions in blood cholesterol, adipokines, insulin and fasted glucose; and are more glucose tolerant. Furthermore, transgenic mice perform better on a rotarod challenge and also show a delay in reproduction. Our findings suggest that increased expression of SIRT1 in mice elicits beneficial phenotypes that may be relevant to human health and longevity.

Journal

Aging CellWiley

Published: Dec 1, 2007

Keywords: calorie restriction; SIRT1; transgenic mice

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