Access the full text.
Sign up today, get DeepDyve free for 14 days.
G. Higgins (1931)
Experimental pathology of the liver, 12
M. Omura, M. Yamaguchi (1999)
Effect of anti-regucalcin antibody on neutral phosphatase activity in rat liver cytosol: Involvement of endogenous regucalcinMolecular and Cellular Biochemistry, 197
B. Burgess, T. Jones (1969)
Search for the Effect of Stellar X-rays on the Night-time Lower IonosphereNature, 224
O. Lowry, N. Rosebrough, A. Farr, R. Randall (1951)
Protein measurement with the Folin phenol reagent.The Journal of biological chemistry, 193 1
Y. Tsurusaki, H. Misawa, M. Yamaguchi (2000)
Translocation of regucalcin to rat liver nucleus: involvement of nuclear protein kinase and protein phosphatase regulation.International journal of molecular medicine, 6 6
R. Bosser, R. Aligue, D. Guerini, N. Agell, E. Carafoli, O. Bachs (1993)
Calmodulin can modulate protein phosphorylation in rat liver cells nuclei.The Journal of biological chemistry, 268 21
K. Burton (1956)
A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid.The Biochemical journal, 62 2
O. Bachs, L. Lanini, J. Serratosa, M. Coll, R. Bastos, R. Aligue, E. Rius, E. Carafoli (1990)
Calmodulin-binding proteins in the nuclei of quiescent and proliferatively activated rat liver cells.The Journal of biological chemistry, 265 30
N. Shimokawa, M. Yamaguchi (1992)
Calcium administration stimulates the expression of calcium‐binding protein regucalcin mRNA in rat liverFEBS Letters, 305
M. Yamaguchi, Y. Kanayama (1996)
Calcium-binding protein regucalcin inhibits deoxyribonucleic acid synthesis in the nuclei of regenerating rat liverMolecular and Cellular Biochemistry, 162
N. Matter, M. Ritz, S. Freyermuth, P. Rogue, A. Malviya (1993)
Stimulation of nuclear protein kinase C leads to phosphorylation of nuclear inositol 1,4,5-trisphosphate receptor and accelerated calcium release by inositol 1,4,5-trisphosphate from isolated rat liver nuclei.The Journal of biological chemistry, 268 1
M. Yamaguchi, S. Ueoka (1997)
Inhibitory effect of calcium-binding protein regucalcin on ribonucleic acid synthesis in isolated rat liver nucleiMolecular and Cellular Biochemistry, 173
Nancy Allbritton, Elena Oancea, Michael Kuhn, Tobias Meyer (1994)
Source of nuclear calcium signals.Proceedings of the National Academy of Sciences of the United States of America, 91 26
M. Yamaguchi (2000)
Role of regucalcin in calcium signaling.Life sciences, 66 19
M. Yamaguchi, T. Yamamoto (1978)
Purification of calcium binding substance from soluble fraction of normal rat liver.Chemical & pharmaceutical bulletin, 26 6
M. Yamaguchi, Y. Kanayama (1995)
Enhanced expression of calcium‐binding protein regucalcin mRNA in regenerating rat liverJournal of Cellular Biochemistry, 57
J. Williamson, R. Cooper, J. Hoek (1981)
Role of calcium in the hormonal regulation of liver metabolism.Biochimica et biophysica acta, 639 3-4
M. Yamaguchi (2000)
The role of regucalcin in nuclear regulation of regenerating liver.Biochemical and biophysical research communications, 276 1
S. Weiss (1960)
ENZYMATIC INCORPORATION OF RIBONUCLEOSIDE TRIPHOSPHATES INTO THE INTERPOLYNUCLEOTIDE LINKAGES OF RIBONUCLEIC ACID.Proceedings of the National Academy of Sciences of the United States of America, 46 8
T. Katsumata, M. Yamaguchi (1998)
Inhibitory effect of calcium‐binding protein regucalcin on protein kinase activity in the nuclei of regenerating rat liverJournal of Cellular Biochemistry, 71
P. Nicotera, David McConkey, Dean Jones, S. Orrenius (1989)
ATP stimulates Ca2+ uptake and increases the free Ca2+ concentration in isolated rat liver nuclei.Proceedings of the National Academy of Sciences of the United States of America, 86 2
Dean Jones, David McConkey, P. Nicotera, S. Orrenius (1989)
Calcium-activated DNA fragmentation in rat liver nuclei.The Journal of biological chemistry, 264 11
M. Yamaguchi, M. Isogai (1993)
Tissue concentration of calcium-binding protein regucalcin in rats by enzyme-linked immunoadsorbent assayMolecular and Cellular Biochemistry, 122
J. Weßendorf, S. Garfinkel, Xi Zhan, Sondi Brown, Thomas MaciagS (1993)
Identification of a nuclear localization sequence within the structure of the human interleukin-1 alpha precursor.The Journal of biological chemistry, 268 29
M. Omura, M. Yamaguchi (1999)
Regulation of protein phosphatase activity by regucalcin localization in rat liver nucleiJournal of Cellular Biochemistry, 75
M. Omura, M. Yamaguchi (1999)
Enhancement of neutral phosphatase activity in the cytosol and nuclei of regenerating rat liver: Role of endogenous regucalcinJournal of Cellular Biochemistry, 73
GH Higgins, RM Anderson (1931)
Experimental pathology of the liver. Restoration of the liver of the white rat following partial surgical removal, 12
N. Kraus-Friedmann, Li Feng (1996)
The role of intracellular Ca2+ in the regulation of gluconeogenesis.Metabolism: clinical and experimental, 45 3
G. Higgins, R. Anderson, G. Higgins, Rm Anderson (1931)
Experimental pathology of liver: restoration of liver in white rat following partial surgical removal
J. Pardo, F. Fernández (1982)
Effect of calcium and calmodulin on RNA synthesis in isolated nuclei from rat liver cellsFEBS Letters, 143
Y. Tsurusaki, M. Yamaguchi (2002)
Suppressive role of endogenous regucalcin in the enhancement of deoxyribonucleic acid synthesis activity in the nucleus of regenerating rat liverJournal of Cellular Biochemistry, 85
A. Martelli, N. Sang, P. Borgatti, S. Capitani, L. Neri (1999)
Multiple biological responses activated by nuclear protein kinase CJournal of Cellular Biochemistry, 74
Wenyu Zhang, John Lee, S. Kumar, M. Gowen (1999)
ERK Pathway Mediates the Activation of Cdk2 in IGF‐1–Induced Proliferation of Human Osteosarcoma MG‐63 CellsJournal of Bone and Mineral Research, 14
M. Yamaguchi, K. Oishi (1993)
Characterization of Ca2+-stimulated adenosine 5′-triphosphatase and Ca2+ sequestering in rat liver nucleiMolecular and Cellular Biochemistry, 125
U. Laemmli (1970)
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4Nature, 227
Oriol Bachss, E. Carafoli (1987)
Calmodulin and calmodulin-binding proteins in liver cell nuclei.The Journal of biological chemistry, 262 22
T. Tamaoki, H. Nomoto, I. Takahashi, Y. Kato, M. Morimoto, F. Tomita (1986)
Staurosporine, a potent inhibitor of phospholipid/Ca++dependent protein kinase.Biochemical and biophysical research communications, 135 2
T. Hunter (1995)
Protein kinases and phosphatases: The Yin and Yang of protein phosphorylation and signalingCell, 80
N Matter, M‐F Ritz, S Fregermuth, P Rague, AN Malviya (1993)
Stimulation of nuclear protein kinase C leads to phosphorylation of nuclear protein kinase C leads to phosphorylation of nuclear inositol 1, 4, 5‐trisphoaphate receptor and accelerated calcium release by inositol 1, 4, 5‐trisphosphate from isolated rat liver nuclei, 268
The role of endogenous regucalcin in the regulation of ribonucleic acid (RNA) synthesis activity in the nucleus of normal and regenerating rat livers was investigated. Nuclear RNA synthesis was measured by the incorporation of [3H]‐uridine 5′‐triphosphate into the nuclear RNA in vitro. The presence of regucalcin (0.25 or 0.5 μM) in the reaction mixture caused a significant decrease in nuclear RNA synthesis of normal rat liver. α‐Amanitin (10−8–10−6 M), an inhibitor of RNA polymerase II and III, decreased significantly nuclear RNA synthesis activity. The effect of regucalcin (0.25 μM) in decreasing nuclear RNA synthesis activity was not seen in the presence of α‐amanitin (10−6 M). The calcium chloride (10 μM)‐increased nuclear RNA synthesis activity was significantly suppressed by the addition of regucalcin (0.25 μM). RNA synthesis activity was significantly enhanced in the nuclei of regenating rat liver obtained at 24, 48, or 72 h after partial hepatectomy. This enhancement was significantly inhibited in the presence of PD98059 (10−5 M), staurosporine (10−6 M), or vanadate (10−3 M). Western analysis of the nuclei of regenerating liver obtained at 24, 48, or 72 h after partial hepatectomy showed a significant increase in regucalcin protein as compared with that of sham‐operated rats. The presence of anti‐regucalcin monoclonal antibody (25 or 50 ng/ml) in the reaction mixture caused a significant increase in nuclear RNA synthesis activity of normal rat liver. This increase was completely blocked by the addition of regucalcin (1.0 μM). The effect of anti‐regucalcin monoclonal antibody (50 ng/ml) in increasing nuclear RNA synthesis activity was significantly enhanced in the nuclei of regenerating liver obtained at 24, 48, or 72 h after partial hepatectomy. This enhancement was significantly suppressed by the addition of α‐amanitin (10−6 M), PD98059 (10−5 M), staurosporine (10−6 M), or vanadate (10−3 M) in the reaction mixture. The present study demonstrates that endogenous regucalcin has a suppressive effect on the enhancement of RNA synthesis activity in the nucleus of regenerating rat liver with proliferative cells. J. Cell. Biochem. 87: 450–457, 2002. © 2002 Wiley‐Liss, Inc.
Journal of Cellular Biochemistry – Wiley
Published: Jan 1, 2002
Keywords: ; ; ; ;
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.