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Release of bovine serum albumin from a hydrogel‐cored biodegradable polymer fiber

Release of bovine serum albumin from a hydrogel‐cored biodegradable polymer fiber We have developed a novel biodegradable, polymeric fiber construct that is coextruded using a wet‐spinning process into a core‐sheath format with a polysaccharide pre‐hydrogel solution as the core fluid and poly(L‐lactic acid) (PLLA) as the sheath. The biodegradable, biocompatible fibers were extruded from polymeric emulsions comprised of solutions of various molecular weights of PLLA dissolved in chloroform and containing dispersed, protein‐free aqueous phases comprising up to 10% of the emulsion volume. Biologically sensitive agents can be loaded via a dispersed aqueous phase in the polymer, and/or directly into the polysaccharide. We show that this core‐sheath fiber format will load a model protein that can be delivered for extended periods in vitro. Bovine serum albumin (BSA) was loaded into the fiber core as a model protein. We have shown that the greater the volume of the protein‐free aqueous phase dispersed into the polymeric continuous‐phase emulsion, the greater the total release of BSA encapsulated by a core gel comprised of 1% sodium alginate solution. We conclude this fiber format provides a promising vehicle for in vivo delivery of biological molecules. Its biocompatibility and biodegradability also allow for its use as a possible substrate for tissue engineering applications. © 2006 Wiley Periodicals, Inc. Biopolymers 81: 419–427, 2006 This article was originally published online as an accepted preprint. The “Published Online” date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at biopolymers@wiley.com http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Biopolymers Wiley

Release of bovine serum albumin from a hydrogel‐cored biodegradable polymer fiber

Crow, B. B.; Nelson, K. D.
Biopolymers , Volume 81 (6) – Apr 15, 2006
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References (30)

Publisher
Wiley
Copyright
Copyright © 2006 Wiley Periodicals, Inc., A Wiley Company
ISSN
0006-3525
eISSN
1097-0282
DOI
10.1002/bip.20442
pmid
16419061
Publisher site
See Article on Publisher Site

Abstract

We have developed a novel biodegradable, polymeric fiber construct that is coextruded using a wet‐spinning process into a core‐sheath format with a polysaccharide pre‐hydrogel solution as the core fluid and poly(L‐lactic acid) (PLLA) as the sheath. The biodegradable, biocompatible fibers were extruded from polymeric emulsions comprised of solutions of various molecular weights of PLLA dissolved in chloroform and containing dispersed, protein‐free aqueous phases comprising up to 10% of the emulsion volume. Biologically sensitive agents can be loaded via a dispersed aqueous phase in the polymer, and/or directly into the polysaccharide. We show that this core‐sheath fiber format will load a model protein that can be delivered for extended periods in vitro. Bovine serum albumin (BSA) was loaded into the fiber core as a model protein. We have shown that the greater the volume of the protein‐free aqueous phase dispersed into the polymeric continuous‐phase emulsion, the greater the total release of BSA encapsulated by a core gel comprised of 1% sodium alginate solution. We conclude this fiber format provides a promising vehicle for in vivo delivery of biological molecules. Its biocompatibility and biodegradability also allow for its use as a possible substrate for tissue engineering applications. © 2006 Wiley Periodicals, Inc. Biopolymers 81: 419–427, 2006 This article was originally published online as an accepted preprint. The “Published Online” date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at biopolymers@wiley.com

Journal

Biopolymers – Wiley

Published: Apr 15, 2006

Keywords: bovine serum albumin (BSA); hydrogel; poly( L ‐lactic acid) (PLLA); extrusion; wet spinning; polysaccharide; fiber

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