Access the full text.
Sign up today, get DeepDyve free for 14 days.
E. Hsu, Z. Ordal (1970)
Comparative Metabolism of Vegetative and Sporulating Cultures of Clostridium thermosaccharolyticumJournal of Bacteriology, 102
Ronald Davies, Marjory Stephenson (1941)
Studies on the acetone-butyl alcohol fermentation: Nutritional and other factors involved in the preparation of active suspensions of Cl. acetobutylicum (Weizmann).The Biochemical journal, 35 12
Monot (1983)
213Biotechnol. Lett., 5
C. Cooney (1979)
CONTINUOUS CULTURE OF MICROORGANISMS: AN OVERVIEW AND PERSPECTIVE *Annals of the New York Academy of Sciences, 326
Thauer (1977)
100Bad. Rev., 41
G. Stephens, R. Holt, J. Gottschal, J. Morris (1985)
Studies on the stability of solvent production by Clostridium acetobutylicum in continuous cultureJournal of Applied Microbiology, 58
J. Roos, Joseph Mclaughlin, E. Papoutsakis (1985)
The effect of pH on nitrogen supply, cell lysis, and solvent production in fermentations of Clostridium acetobutylicumBiotechnology and Bioengineering, 27
Harrison (1974)
167Adv. Biochem. Eng., 3
J. Ballongue, J. Amine, E. Masion, H. Petitdemange (1985)
Induction of acetoacetate decarboxylase in Clostridium acetobutylicumFems Microbiology Letters, 29
Hartmanis (1984)
66Appl. Microbiol. Biotechnol., 20
Leung (1981)
348Proc. 2nd World Cong. Chem. Eng., 1
S. Long, David Jones, D. Woods (1983)
Sporulation of Clostridium acetobutylicum P262 in a Defined MediumApplied and Environmental Microbiology, 45
Bahl (1982)
201Eur. J. Appl. Microbiol. Biotechnol., 15
D. Jones, A. Westhuizen, S. Long, E. Allcock, S. Reid, D. Woods (1982)
Solvent Production and Morphological Changes in Clostridium acetobutylicumApplied and Environmental Microbiology, 43
K. Clarke, G. Hansford (1986)
PRODUCTION OF ACETONE AND BUTANOL BY CLOSTRIDIUM ACETOBUTYLICUM IN A PRODUCT LIMITED CHEMOSTATChemical Engineering Communications, 45
Andersch (1983)
327Eur. J. Appl. Microbiol. Biotechnol., 18
Long (1984)
529Biotechnol. Lett., 6
Long (1984)
256Appl. Microbiol. Biotechnol., 20
Bahl (1985)
217Biotechnol. Bioeng. Symp., 14
Gottschal (1982)
477Biotechnol. Lett., 4
Spivey (1978)
2Proc. Biochem., 13
M. Hartmanis, S. Gatenbeck (1984)
Intermediary Metabolism in Clostridium acetobutylicum: Levels of Enzymes Involved in the Formation of Acetate and ButyrateApplied and Environmental Microbiology, 47
SANDRA LANDUYT, E. Hsu, Mei Lu (1983)
Transition from Acid Fermentation to Solvent Fermentation in a Continuous Dilution Culture of Clostridium thermosaccharolyticumAnnals of the New York Academy of Sciences, 413
10.1002/bit.260320417.abs The concurrent production of acids and solvents and the production of acetone during continuous culture in a product‐limited chemostat indicated that the culture contained a mixture of acid‐ and solvent‐producing cells. Periodic oscillations in the yield of end products and the specific growth rate of the culture were ob served during undisturbed continuous culture at a constant dilution rate. The increased specific growth rate was associated with an increased acid yield and an increase in the rate of cell division and the proportion of short rods. The decreased specific growth rate was as sociated with an increase in the solvent yield and a decrease in the rate of cell division, resulting in the production of elongated rods. It is proposed that the oscillatory behavior observed during continuous culture is an inherent characteristic related to the shift from primary to secondary metabolism. A major consequence of the oscillation of the specific rates of growth and division in cultures containing acid‐ and solvent‐producing cells is that it precludes the attainment of a true steady state during continuous culture.
Biotechnology and Bioengineering – Wiley
Published: Aug 5, 1988
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.