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C. Boer, S. Loyson, P. Kluin, H. Kluin-Nelemans, E. Schuuring, J. Krieken (1993)
Multiple breakpoints within the BCL-1 locus in B-cell lymphoma: rearrangements of the cyclin D1 gene.Cancer research, 53 18
Y. Tsujimoto, E. Jaffe, J. Cossman, J. Gorham, P. Nowell, C. Croce (1985)
Clustering of breakpoints on chromosome 11 in human B-cell neoplasms with the t(11 ; 14) chromosome translocationNature, 315
Martin Dyer, P. Fischer, Elisabeth Nacheva, W. Labastide, A. Karpas (1990)
A new human B-cell non-Hodgkin's lymphoma cell line (Karpas 422) exhibiting both t (14;18) and t(4;11) chromosomal translocations.Blood, 75 3
Y. Xiong, T. Connolly, B. Futcher, D. Beach (1991)
Human D-type cyclinCell, 65
P. Gaudray, P. Szepetowski, C. Escot, D. Birnbaum, C. Theillet (1992)
DNA amplification at 11q13 in human cancer: from complexity to perplexity.Mutation research, 276 3
T. Meeker, J. Grimaldi, R. O'rourke, E. Louie, G. Juliusson, S. Einhorn (1989)
An additional breakpoint region in the BCL-1 locus associated with the t(11;14)(q13;q32) translocation of B-lymphocytic malignancy.Blood, 74 5
R. Rimokh, F. Berger, P. Cornillet, K. Wahbi, J. Rouault, M. Ffrench, P. Bryon, Myfène Gadoux, O. Gentilhomme, D. Germain, J. Magaud (1990)
Break in the BCL1 locus is closely associated with intermediate lymphocytic lymphoma subtypeGenes, 2
Berenson, J. Yang, Mickel Ra (1989)
Frequent amplification of the bcl-1 locus in head and neck squamous cell carcinomas.Oncogene, 4 9
Gentilhomme 0, Germain D, Magaud JP (1993) Rearrangement and overexpression of the B C L l P R A D I gene in intermediatc
Berenson, H. Koga, J. Yang, John Pearl, Holmes Ec, Robert Figlin (1990)
Frequent amplification of the bcl-1 locus in poorly differentiated squamous cell carcinoma of the lung. The Lung Cancer Study Group.Oncogene, 5 9
P. Koduru, K. Offit, D. Filippa (1989)
Molecular analysis of breaks in BCL-1 proto-oncogene in B-cell lymphomas with abnormalities of 11q13.Oncogene, 4 7
(1991)
Kro-nenberg HM
M. Williams, S. Swerdlow, C. Rosenberg, A. Arnold (1993)
Chromosome 11 translocation breakpoints at the PRAD1/cyclin D1 gene locus in centrocytic lymphoma.Leukemia, 7 2
(1992)
Michalides RJAM (1992a) Identification and cloning of two overexpressed genes
Meeker Tc, W. Sellers, R. Harvey, D. Withers, K. Carey, H. Xiao, Block Am, B. Dadey, T. Han (1991)
Cloning of the t(11;14)(q13;q32) translocation breakpoints from two human leukemia cell lines.Leukemia, 5 9
(1992)
poor& differentiated squamous cell carcinoma o f the lung
Ed Schuuring, E. Verhoeven, Sergey Litvinov, R.J.A.M. Michalides (1993)
The product of the EMS1 gene, amplified and overexpressed in human carcinomas, is homologous to a v-src substrate and is located in cell-substratum contact sitesMolecular and Cellular Biology, 13
(1991)
Guidelines for Cancer Cytogenetics.
M. Raffeld, E. Jaffe (1991)
bcl-1, t(11;14), and mantle cell-derived lymphomas.Blood, 78 2
Proctor Aj, L. Coombs, Cairns Jp, M. Knowles (1991)
Amplification at chromosome 11q13 in transitional cell tumours of the bladder.Oncogene, 6 5
S. Brookes, G. Lammie, C. Dickson, G. Peters, E. Schuuring (1992)
Linkage map of a region of human chromosome band 11q13 amplified in breast and squamous cell tumorsGenes, 4
Bekri S. Leroux D, Grosgeorge J, Klein B, Bastard C, Gaudray P
Lammie Ga, Fantl, Rosali Smith, E. Schuuring, S. Brookes, R. Michalides, C. Dickson, A. Arnold, G. Peters (1991)
D11S287, a putative oncogene on chromosome 11q13, is amplified and expressed in squamous cell and mammary carcinomas and linked to BCL-1.Oncogene, 6 3
Ed Schuuring, Els Verhoeven, H. Tinteren, J. Peterse, Brigitte Nunnink, M. FredericB.J., Thunnissen, P. Devilee, C. Cornelisse, M. Vijver, Woher Mooi, R.J.A.M. Michalides (1992)
Amplification of genes within the chromosome 11q13 region is indicative of poor prognosis in patients with operable breast cancer.Cancer research, 52 19
C. Nguyen, D. Roux, M. Mattei, O. Delapeyrière, M. Goldfarb, D. Birnbaum, B. Jordan (1988)
The FGF-related oncogenes hst and int.2, and the bcl.1 locus are contained within one megabase in band q13 of chromosome 11, while the fgf.5 oncogene maps to 4q21.Oncogene, 3 6
J. Faust, T. Meeker (1992)
Amplification and expression of the bcl-1 gene in human solid tumor cell lines.Cancer research, 52 9
(1993)
Deregulation of the cyclin DI gene does not account for all 1 lq13 alterations, even t( 1 I
D. Withers, R. Harvey, J. Faust, Ostap, Melnyk, K. Carey, T. Meeker (1991)
Characterization of a candidate bcl-1 geneMolecular and Cellular Biology, 11
J. Ravetch, U. Siebenlist, S. Korsmeyer, T. Waldmann, P. Leder (1981)
Structure of the human immunoglobulin μ locus: Characterization of embryonic and rearranged J and D genesCell, 27
T. Ohtsuki, Y. Yawata, H. Wada, T. Sugihara, M. Mori, M. Namba (1989)
Two human myeloma cell lines, amylase‐producing KMS‐12‐PE and amylase‐non‐producing KMS‐12‐BM, were established from a patient, having the same chromosome marker, t(11;14)(q13;q32)British Journal of Haematology, 73
C. Theillet, X. Leroy, O. Delapeyrière, J. Grosgeorges, J. Adnane, S. Raynaud, J. Simony‐Lafontaine, M. Goldfarb, C. Escot, D. Birnbaum (1989)
Amplification of FGF-related genes in human tumors: possible involvement of HST in breast carcinomas.Oncogene, 4 7
R. Rimokh, F. Berger, G. Delsol, C. Charrin, Marie-Francoise Berthbas, M. Ffrench, M. Garoscio, P. Felman, B. Coiffier, Michel Gentilhomme, D. Germain, J. Magaud (1993)
Rearrangement and overexpression of the BCL-1/PRAD-1 gene in intermediate lymphocytic lymphomas and in t(11q13)-bearing leukemias.Blood, 81 11
PhD MD, Gloria Dermatology (2020)
Molecular AnalysisDefinitions
T. Motokura, T. Bloom, Hyung Kim, H. Jüppner, J. Ruderman, H. Kronenberg, A. Arnold (1991)
A novel cyclin encoded by a bcl1-linked candidate oncogeneNature, 350
S. Raynaud, S. Bekri, D. Leroux, J. Grosgeorge, B. Klein, C. Bastard, P. Gaudray, M. Simon (1993)
Expanded range of 11q13 breakpoints with differing patterns of cyclin D1 expression in B‐cell malignanciesGenes, 8
(1988)
FGF-related oncogenes hst-I
P. Rabbitts, J. Douglas, P. Fischer, E. Nacheva, A. Karpas, D. Catovsky, J. Melo, R. Baer, M. Stinson, T. Rabbitts (1988)
Chromosome abnormalities at 11q13 in B cell tumoursOncogene, 3
T. Motokura, A. Arnold (1993)
PRAD1/lCyclin D1 proto‐oncogene: Genomic organization, 5′ dna sequence, and sequence of a tumor‐specific rearrangement breakpointGenes, 7
(1991)
Translocation ( I l:l4)
(1992)
hleeker
M. Seto, Kazuhide Yamamoto, S. Iida, Y. Akao, Utsumi Kr, I. Kubonishi, I. Miyoshi, T. Ohtsuki, Y. Yawata, M. Namba (1992)
Gene rearrangement and overexpression of PRAD1 in lymphoid malignancy with t(11;14)(q13;q32) translocation.Oncogene, 7 7
Expression of the PRADf gene in HO cells and in different cell lines. Polyadenylated RNA samples (5 pg) were hybridized with the pradl cDNA probe (A)
D. Lew, V. Dulić, S. Reed (1991)
Isolation of three novel human cyclins by rescue of G1 cyclin (cln) function in yeastCell, 66
D. Leroux, F. Marc’hadour, R. Gressin, M. Jacob, E. Keddari, M. Monteil, P. Caillot, P. Jalbert, J. Sotto (1991)
Non‐Hodgkin's lymphomas with t(11;14)(q13;q32): a subset of mantle zone/intermediate lymphocytic lymphoma?British Journal of Haematology, 77
(1992)
Namba
É., D., H.
Genotypic Characterization of Centrocytic Lymphoma : Frequent Rearrangement of the Chromosome 11 bcl-1 Locus
J. Chirgwin, A. Przybyla, Raymond MacDonald, W. Rutter (1979)
Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease.Biochemistry, 18 24
Michael Williams, T. Meeker, S. Swerdlow (1991)
Rearrangement of the chromosome 11 bcl-1 locus in centrocytic lymphoma: analysis with multiple breakpoint probesBlood, 78
E. Vandenberghe, C. Wolf‐Peeters, J. Oord, I. Wlodarska, J. Delabie, M. Stul, J. Thomas, J. Michaux, C. Mecucci, J. Cassiman, H. Berghe (1991)
Translocation (11;14): A cytogenetic anomaly associated with B‐cell lymphomas of non‐follicle centre cell lineageThe Journal of Pathology, 163
(1988)
hlarrei
(1992)
Thcillet
E. Schuuring, E. Verhoeven, W. Mooi, R. Michalides (1992)
Identification and cloning of two overexpressed genes, U21B31/PRAD1 and EMS1, within the amplified chromosome 11q13 region in human carcinomas.Oncogene, 7 2
M. Williams, S. Swerdlow, C. Rosenberg, A. Arnold (1992)
Characterization of chromosome 11 translocation breakpoints at the bcl-1 and PRAD1 loci in centrocytic lymphoma.Cancer research, 52 19 Suppl
M. Williams, Cindy Westermann, S. Swerdlow (1990)
Genotypic characterization of centrocytic lymphoma: frequent rearrangement of the chromosome 11 bcl-1 locus.Blood, 76 7
G. Chu, D. Vollrath, R. Davis (1986)
Separation of large DNA molecules by contour-clamped homogeneous electric fields.Science, 234 4783
Y. Tsujimoto, J. Yunis, L. Onorato-Showe, J. Erikson, P. Nowell, C. Croce (1984)
Molecular cloning of the chromosomal breakpoint of B-cell lymphomas and leukemias with the t(11;14) chromosome translocation.Science, 224 4656
C. Rosenberg, Emily Wong, E. Petty, A. Bale, Y. Tsujimoto, Nanch Harris, A. Arnold (1991)
PRAD1, a candidate BCL1 oncogene: mapping and expression in centrocytic lymphoma.Proceedings of the National Academy of Sciences of the United States of America, 88
Karpas .4, Carovsky D, 5lelo JV. Baer R, Stinson 11.4, Rabbitts T H (1988) Chromosome abnormalities ar l l q 1 3 in B cell rumours
In B‐cell malignancies, the t(11;14)(q13;q32) at the 11q13 BCLI locus is characterized by a scattering of breakpoint sites along a 100 kb genomic region, between the BCLI major translocation cluster (MTC) and the PRADI (also termed cyclin DI or CCNDI) gene. Recently, the 11q13 breakpoint region was extended on both sides, centromeric to the MTC and telomeric to PRADI. We report here the molecular cloning of a new t(11;14) breakpoint site, 20 kb centromeric to the MTC, from a patient with prolymphocytic leukemia. We subcloned a non‐repetitive DNA fragment near the breakpoint and mapped this new 11q13 probe (pHOIIc) relative to already identified breakpoint sites, using long‐ and short‐range physical mapping within the BCLI locus. Rearrangements in the BCLI locus are associated with deregulation of the PRADI gene, which is often overexpressed, particularly in mantle‐cell malignancies. The detectable but weak PRADI expression in the case we present suggests that this breakpoint centromeric to the MTC still lies inside the BCLI locus boundaries. We think that attention should be focused on this region centromeric to the BCLI‐MTC, where the investigation of previously unidentified translocations may increase understanding of the PRADI gene deregulation in t(11;14) associated pathologies.
Genes, Chromosomes and Cancer – Wiley
Published: Dec 1, 1994
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