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H. Cohen, Christine Miller, Kevin Bitterman, N. Wall, B. Hekking, B. Kessler, K. Howitz, M. Gorospe, R. Cabo, D. Sinclair (2004)
Calorie Restriction Promotes Mammalian Cell Survival by Inducing the SIRT1 DeacetylaseScience, 305
M. Duchen (2004)
Roles of mitochondria in health and disease.Diabetes, 53 Suppl 1
J. Vanfleteren, B. Braeckman (1999)
Mechanisms of life span determination in Caenorhabditis elegans☆Neurobiology of Aging, 20
Y. Higami, T. Pugh, G. Page, D. Allison, T. Prolla, R. Weindruch (2004)
Adipose tissue energy metabolism: altered gene expression profile of mice subjected to long‐term caloric restrictionThe FASEB Journal, 18
Y. Sugimoto, R. Erikson (1985)
Phosphatidylinositol kinase activities in normal and Rous sarcoma virus-transformed cellsMolecular and Cellular Biology, 5
Kevin Bitterman, Rozalyn Anderson, H. Cohen, Magda Latorre-Esteves, D. Sinclair (2002)
Inhibition of Silencing and Accelerated Aging by Nicotinamide, a Putative Negative Regulator of Yeast Sir2 and Human SIRT1*The Journal of Biological Chemistry, 277
Su-Ju Lin, M. Kaeberlein, Alex Andalis, Lori Sturtz, P. Defossez, V. Culotta, G. Fink, L. Guarente (2002)
Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respirationNature, 418
B. Spiegelman, J. Flier (2001)
Obesity and the Regulation of Energy BalanceCell, 104
Jennie Dorman, B. Albinder, Terry Shroyer, Cynthia Kenyon (1995)
The age-1 and daf-2 genes function in a common pathway to control the lifespan of Caenorhabditis elegans.Genetics, 141 4
W. Cefalu, J. Wagner, Z. Wang, A. Bell-Farrow, J. Collins, D. Haskell, R. Bechtold, Trefor Morgan (1997)
A study of caloric restriction and cardiovascular aging in cynomolgus monkeys (Macaca fascicularis): a potential model for aging research.The journals of gerontology. Series A, Biological sciences and medical sciences, 52 1
M. Katić, C. Kahn (2005)
The role of insulin and IGF-1 signaling in longevityCellular and Molecular Life Sciences CMLS, 62
L. Guarente, C. Kenyon (2000)
Genetic pathways that regulate ageing in model organismsNature, 408
E. Fraze, Y. Chiou, Ydi Chen, G. Reaven (1987)
Age‐Related Changes in Postprandial Plasma Glucose, Insulin, and Free Fatty Acid Concentrations in Nondiabetic IndividualsJournal of the American Geriatrics Society, 35
J. Kerner, P. Turkaly, P. Minkler, C. Hoppel (2001)
Aging skeletal muscle mitochondria in the rat: decreased uncoupling protein-3 content.American journal of physiology. Endocrinology and metabolism, 281 5
J. Greenberg, C. Boozer (2000)
Metabolic mass, metabolic rate, caloric restriction, and aging in male Fischer 344 ratsMechanisms of Ageing and Development, 113
Cheng Li, W. Wong (2001)
Model-based analysis of oligonucleotide arrays: expression index computation and outlier detection.Proceedings of the National Academy of Sciences of the United States of America, 98 1
Y. Kagawa (1978)
Impact of Westernization on the nutrition of Japanese: changes in physique, cancer, longevity and centenarians.Preventive medicine, 7 2
S. Nemoto, M. Fergusson, T. Finkel (2005)
SIRT1 Functionally Interacts with the Metabolic Regulator and Transcriptional Coactivator PGC-1α*Journal of Biological Chemistry, 280
J. Ojaimi, C. Masters, K. Opeskin, P. Mckelvie, E. Byrne (1999)
Mitochondrial respiratory chain activity in the human brain as a function of ageMechanisms of Ageing and Development, 111
K. Petersen, D. Befroy, S. Dufour, J. Dziura, C. Ariyan, D. Rothman, L. DiPietro, G. Cline, G. Shulman (2003)
Mitochondrial Dysfunction in the Elderly: Possible Role in Insulin ResistanceScience, 300
Su-Ju Lin, P. Defossez, L. Guarente (2000)
Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae.Science, 289 5487
Inmaculada Valle, A. Alvarez-Barrientos, E. Arza, S. Lamas, M. Monsalve (2005)
PGC-1α regulates the mitochondrial antioxidant defense system in vascular endothelial cellsCardiovascular Research, 66
J. Speakman, Darren Talbot, C. Selman, S. Snart, J. McLaren, P. Redman, Ela Krol, D. Jackson, Maria Johnson, M. Brand (2004)
Uncoupled and surviving: individual mice with high metabolism have greater mitochondrial uncoupling and live longerAging Cell, 3
D. Vicent, J. Ilany, Tatsuya Kondo, K. Naruse, S. Fisher, Y. Kisanuki, S. Bursell, M. Yanagisawa, G. King, C. Kahn (2003)
The role of endothelial insulin signaling in the regulation of vascular tone and insulin resistance.The Journal of clinical investigation, 111 9
A. Dillin, A. Hsu, N. Arantes-Oliveira, J. Lehrer-Graiwer, H. Hsin, A. Fraser, R. Kamath, J. Ahringer, C. Kenyon (2002)
Rates of Behavior and Aging Specified by Mitochondrial Function During DevelopmentScience, 298
V. Yechoor, M. Patti, K. Ueki, P. Laustsen, Robert Saccone, R. Rauniyar, C. Kahn (2004)
Distinct pathways of insulin-regulated versus diabetes-regulated gene expression: an in vivo analysis in MIRKO mice.Proceedings of the National Academy of Sciences of the United States of America, 101 47
V. Katuri, A. Dillner, Bibhuti Mishra, Chu-Xia Deng, Lopa Mishra (2003)
Extended Longevity in Mice Lacking the Insulin Receptor in Adipose TissueScience, 299
B. Rogina, S. Helfand, S. Frankel (2002)
Longevity Regulation by Drosophila Rpd3 Deacetylase and Caloric RestrictionScience, 298
H. Tissenbaum, L. Guarente (2001)
Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegansNature, 410
B. Rogina, S. Helfand (2004)
Sir2 mediates longevity in the fly through a pathway related to calorie restriction.Proceedings of the National Academy of Sciences of the United States of America, 101 45
S. Vij, Jason Nomi, Dina Dajani, L. Uddin
Age-related changes in
Tong Shi, Fei Wang, Emily Stieren, Q. Tong (2005)
SIRT3, a Mitochondrial Sirtuin Deacetylase, Regulates Mitochondrial Function and Thermogenesis in Brown Adipocytes*Journal of Biological Chemistry, 280
M. Holzenberger, J. Dupont, B. Ducos, P. Leneuve, A. Géloën, P. Even, P. Cervera, Y. Bouc (2003)
IGF-1 receptor regulates lifespan and resistance to oxidative stress in miceNature, 421
M. Mańczak, Youngsin Jung, Byung Park, Dara Partovi, P. Reddy (2005)
Time‐course of mitochondrial gene expressions in mice brains: implications for mitochondrial dysfunction, oxidative damage, and cytochrome c in agingJournal of Neurochemistry, 92
M. Barros, Brian Bandy, E. Tahara, A. Kowaltowski (2004)
Higher Respiratory Activity Decreases Mitochondrial Reactive Oxygen Release and Increases Life Span in Saccharomyces cerevisiae*Journal of Biological Chemistry, 279
D. Wisniewski, A. Strife, S. Swendeman, H. Erdjument-Bromage, S. Geromanos, W. Kavanaugh, P. Tempst, B. Clarkson (1999)
A novel SH2-containing phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase (SHIP2) is constitutively tyrosine phosphorylated and associated with src homologous and collagen gene (SHC) in chronic myelogenous leukemia progenitor cells.Blood, 93 8
C. Selman, T. Phillips, J. Staib, J. Duncan, C. Leeuwenburgh, J. Speakman (2005)
Energy expenditure of calorically restricted rats is higher than predicted from their altered body compositionMechanisms of Ageing and Development, 126
F. Facchini, N. Hua, F. Abbasi, G. Reaven (2001)
Insulin resistance as a predictor of age-related diseases.The Journal of clinical endocrinology and metabolism, 86 8
D. Harman (1956)
Aging: a theory based on free radical and radiation chemistry.Journal of gerontology, 11 3
D. Clancy, D. Gems, L. Harshman, S. Oldham, Hugo Stocker, E. Hafen, S. Leevers, Linda Partridge (2001)
Extension of Life-Span by Loss of CHICO, a Drosophila Insulin Receptor Substrate ProteinScience, 292
R. Walford, D. Mock, R. Verdery, T. Maccallum (2002)
Calorie restriction in biosphere 2: alterations in physiologic, hematologic, hormonal, and biochemical parameters in humans restricted for a 2-year period.The journals of gerontology. Series A, Biological sciences and medical sciences, 57 6
D. Heemst, M. Beekman, S. Mooijaart, B. Heijmans, Bernd Brandt, B. Zwaan, P. Slagboom, R. Westendorp (2005)
Reduced insulin/IGF‐1 signalling and human longevityAging Cell, 4
N. Barzilai, Swati Banerjee, M. Hawkins, Wei Chen, L. Rossetti (1998)
Caloric restriction reverses hepatic insulin resistance in aging rats by decreasing visceral fat.The Journal of clinical investigation, 101 7
C. Ross (2005)
Folate, mitochondria, ROS, and the aging brain.The American journal of medicine, 118 10
M. Schubert, D. Gautam, D. Surjo, K. Ueki, S. Baudler, D. Schubert, Tatsuya Kondo, J. Alber, N. Galldiks, E. Küstermann, S. Arndt, A. Jacobs, W. Krone, C. Kahn, J. Brüning (2004)
Role for neuronal insulin resistance in neurodegenerative diseases.Proceedings of the National Academy of Sciences of the United States of America, 101 9
W. Kohrt, J. Kirwan, M. Staten, R. Bourey, D. King, J. Holloszy (1993)
Insulin Resistance in Aging Is Related to Abdominal ObesityDiabetes, 42
Christian Weyer, Roy Walford, Ingeborg Harper, Mike Milner, Taber MacCallum, P. Tataranni, Eric Ravussin (2000)
Energy metabolism after 2 y of energy restriction: the biosphere 2 experiment.The American journal of clinical nutrition, 72 4
L. Kwong, R. Sohal (2000)
Age-related changes in activities of mitochondrial electron transport complexes in various tissues of the mouse.Archives of biochemistry and biophysics, 373 1
M. Eisen, P. Spellman, P. Brown, D. Botstein (1998)
Cluster analysis and display of genome-wide expression patterns.Proceedings of the National Academy of Sciences of the United States of America, 95 25
K. Tsukiyama-Kohara, F. Poulin, M. Kohara, C. Demaria, Alan Cheng, Zhidan Wu, A. Gingras, A. Katsume, M. Elchebly, B. Spiegelman, M. Harper, M. Tremblay, N. Sonenberg (2001)
Adipose tissue reduction in mice lacking the translational inhibitor 4E-BP1Nature Medicine, 7
Y. Honda, S. Honda (1999)
The daf‐2 gene network for longevity regulates oxidative stress resistance and Mn‐superoxide dismutase gene expression in Caenorhabditis elegansThe FASEB Journal, 13
G. Martin, S. Austad, T. Johnson (1996)
Genetic analysis of ageing: role of oxidative damage and environmental stressesNature Genetics, 13
H. Kurosu, Masaya Yamamoto, Jeremy Clark, J. Pastor, A. Nandi, Prem Gurnani, O. McGuinness, H. Chikuda, M. Yamaguchi, H. Kawaguchi, I. Shimomura, Y. Takayama, J. Herz, C. Kahn, K. Rosenblatt, M. Kuro-o (2005)
Suppression of Aging in Mice by the Hormone KlothoScience, 309
F. Facchini, C. Hollenbeck, Y. Chen, Ydi Chen, G. Reaven (1992)
Demonstration of a relationship between white blood cell count, insulin resistance, and several risk factors for coronary heart disease in womenJournal of Internal Medicine, 232
(2007)
Role of adipose mitochondria
J. Molero, T. Jensen, P. Withers, M. Couzens, H. Herzog, C. Thien, W. Langdon, K. Walder, M. Murphy, D. Bowtell, D. James, G. Cooney (2004)
c-Cbl-deficient mice have reduced adiposity, higher energy expenditure, and improved peripheral insulin action.The Journal of clinical investigation, 114 9
G. Enzi, M. Gasparo, P. Biondetti, D. Fiore, M. Semisa, F. Zurlo (1986)
Subcutaneous and visceral fat distribution according to sex, age, and overweight, evaluated by computed tomography.The American journal of clinical nutrition, 44 6
Rozalyn Anderson, Kevin Bitterman, Jason Wood, Oliver Medvedik, D. Sinclair (2003)
Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiaeNature, 423
C. Chiu, Wen Lin, Shao-Yong Huang, Ying-Hue Lee (2004)
Effect of a C/EBP gene replacement on mitochondrial biogenesis in fat cells.Genes & development, 18 16
V. Longo, C. Finch (2003)
Evolutionary Medicine: From Dwarf Model Systems to Healthy Centenarians?Science, 299
C. Kenyon (2005)
The Plasticity of Aging: Insights from Long-Lived MutantsCell, 120
M. Brand (2000)
Uncoupling to survive? The role of mitochondrial inefficiency in ageingExperimental Gerontology, 35
M. Patti, A. Butte, Sarah Crunkhorn, K. Cusi, R. Berria, S. Kashyap, Y. Miyazaki, I. Kohane, M. Costello, Robert Saccone, E. Landaker, A. Goldfine, E. Mun, R. DeFronzo, J. Finlayson, C. Kahn, L. Mandarino (2003)
Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1Proceedings of the National Academy of Sciences of the United States of America, 100
Rozalyn Anderson, Magda Latorre-Esteves, A. Neves, Siva Lavu, Oliver Medvedik, Christopher Taylor, K. Howitz, H. Santos, D. Sinclair (2003)
Yeast Life-Span Extension by Calorie Restriction Is Independent of NAD FluctuationScience, 302
B. Martin, J. Warram, A. Krolewski, J. Soeldner, C. Kahn, R. Bergman (1992)
Role of glucose and insulin resistance in development of type 2 diabetes mellitus: results of a 25-year follow-up studyThe Lancet, 340
C. Tiraby, G. Tavernier, C. Lefort, D. Larrouy, F. Bouillaud, D. Ricquier, D. Langin (2003)
Acquirement of Brown Fat Cell Features by Human White Adipocytes*Journal of Biological Chemistry, 278
T. Mcgavack, S. Klotz (1997)
Insulin resistanceBMJ, 314
E. Lesnefsky, T. Gudz, S. Moghaddas, C. Migita, M. Ikeda-Saito, P. Turkaly, C. Hoppel (2001)
Aging decreases electron transport complex III activity in heart interfibrillar mitochondria by alteration of the cytochrome c binding site.Journal of molecular and cellular cardiology, 33 1
J. Mattison, M. Lane, G. Roth, D. Ingram (2003)
Calorie restriction in rhesus monkeysExperimental Gerontology, 38
M. Blüher, M. Michael, O. Peroni, K. Ueki, Nathan Carter, B. Kahn, C. Kahn (2002)
Adipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intolerance.Developmental cell, 3 1
A. Laws, G. Reaven (1993)
Insulin resistance and risk factors for coronary heart disease.Bailliere's clinical endocrinology and metabolism, 7 4
A. Hulbert, D. Clancy, William Mair, B. Braeckman, D. Gems, L. Partridge (2004)
Metabolic rate is not reduced by dietary-restriction or by lowered insulin/IGF-1 signalling and is not correlated with individual lifespan in Drosophila melanogasterExperimental Gerontology, 39
D. Haripriya, M. Devi, V. Kokilavani, Purushotham Sangeetha, C. Panneerselvam (2004)
Age-dependent alterations in mitochondrial enzymes in cortex, striatum and hippocampus of rat brain – potential role of L-CarnitineBiogerontology, 5
P. Onyango, I. Ćelić, J. McCaffery, J. Boeke, A. Feinberg (2002)
SIRT3, a human SIR2 homologue, is an NAD- dependent deacetylase localized to mitochondriaProceedings of the National Academy of Sciences of the United States of America, 99
D. McCulloch, D. Gems (2003)
Body size, insulin/IGF signaling and aging in the nematode Caenorhabditis elegansExperimental Gerontology, 38
C. Lyons, O. Mathieu‐costello, C. Moyes (2006)
Regulation of skeletal muscle mitochondrial content during aging.The journals of gerontology. Series A, Biological sciences and medical sciences, 61 1
Summary Caloric restriction, leanness and decreased activity of insulin/insulin-like growth factor 1 (IGF-1) receptor signaling are associated with increased longevity in a wide range of organisms from Caenorhabditis elegans to humans. Fat-specific insulin receptor knock-out (FIRKO) mice represent an interesting dichotomy, with leanness and increased lifespan, despite normal or increased food intake. To determine the mechanisms by which a lack of insulin signaling in adipose tissue might exert this effect, we performed physiological and gene expression studies in FIRKO and control mice as they aged. At the whole body level, FIRKO mice demonstrated an increase in basal metabolic rate and respiratory exchange ratio. Analysis of gene expression in white adipose tissue (WAT) of FIRKO mice from 6 to 36 months of age revealed persistently high expression of the nuclear-encoded mitochondrial genes involved in glycolysis, tricarboxylic acid cycle, ॆ-oxidation and oxidative phosphorylation as compared to expression of the same genes in WAT from controls that showed a tendency to decline in expression with age. These changes in gene expression were correlated with increased cytochrome c and cytochrome c oxidase subunit IV at the protein level, increased citrate synthase activity, increased expression of peroxisome proliferator-activated receptor े coactivator 1α (PGC-1α) and PGC-1ॆ, and an increase in mitochondrial DNA in WAT of FIRKO mice. Together, these data suggest that maintenance of mitochondrial activity and metabolic rates in adipose tissue may be important contributors to the increased lifespan of the FIRKO mouse.
Aging Cell – Wiley
Published: Dec 1, 2007
Keywords: calorie restriction; diabetes; insulin resistance; mitochondria; obesity; PGC-1α
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