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Metabolites of (+)‐dehydroabietic acid in rabbits

Metabolites of (+)‐dehydroabietic acid in rabbits 10.1002/jps.2600790618.abs The seven metabolites of (+)‐dehydroabietic acid (DHA) were newly isolated from rabbit urine by liquid chromatography. On the basis of chemical and spectral data their structures were established to be (15S)‐8, 11, 13‐abietatrien‐16, 18‐dioic acid, 2α‐hydroxy‐8, 11, 13, 15‐abietatetraen‐18‐oic acid, (15R)‐15, 16‐dihydroxy‐8, 11, 13‐abietatrien‐18‐oic acid, 2β, 15‐dihydroxy‐8, 11, 13‐abietatrien‐18‐oic acid, (15S)‐20, 16‐dihydroxy‐8, 11, 13‐abietatrien‐18‐oic acid, 2α, 15‐dihydroxy‐8, 11, 13‐abietatrien‐18‐oic acid, and (15S)‐2α, 16‐dihydroxy‐8, 11, 13‐abietatrien‐18‐oic acid. The possible hydroxylation routes of DHA in rabbits and the difference between the metabolism of DHA in microorganisms and that in rabbits are discussed. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Pharmaceutical Science Wiley

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