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Maternal effect for genes encoding 6‐phosphogluconate dehydrogenase and glucose‐6‐phosphate dehydrogenase in Drosophila melanogaster

Maternal effect for genes encoding 6‐phosphogluconate dehydrogenase and glucose‐6‐phosphate... We studied the maternal effect for two enzymes of the pentose cycle, 6‐phosphogluconate dehydrogenase (6PGD) and glucose‐6‐phosphate dehydrogenase (G6PD), using a genetic system based on the interaction of Pgd− and Zw− alleles, which inactivate 6PGD and G6PD, respectively. The presence and formation of the enzymes was investigated in those individuals that had not received the corresponding genes from the mother. We revealed maternal forms of the enzymes, detectable up to the pupal stage. The activities of “maternal” 6PGD and G6PD per individual increased 20‐fold to 30‐fold from the egg stage to the 3rd larval instar even in the absence of normal Pgd and Zw genes. Immunologic studies have shown that the increase in 6PGD activity is due to an accumulation of the maternal form of the enzyme molecules. We revealed a hybrid isozyme resulting from an aggregation of the subunits of isozymes controlled by the genes of the mother and embryo itself. These results indicate that the maternal effect in the case of 6PGD is due to a long‐lived stable mRNA transmitted with the egg cytoplasm and translated during the development of Drosophila melanogaster. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Genesis: the Journal of Genetics and Development Wiley

Maternal effect for genes encoding 6‐phosphogluconate dehydrogenase and glucose‐6‐phosphate dehydrogenase in Drosophila melanogaster

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References (28)

Publisher
Wiley
Copyright
"Copyright © 1979 Wiley Subscription Services, Inc., A Wiley Company"
ISSN
1526-954X
eISSN
1526-968X
DOI
10.1002/dvg.1020010110
Publisher site
See Article on Publisher Site

Abstract

We studied the maternal effect for two enzymes of the pentose cycle, 6‐phosphogluconate dehydrogenase (6PGD) and glucose‐6‐phosphate dehydrogenase (G6PD), using a genetic system based on the interaction of Pgd− and Zw− alleles, which inactivate 6PGD and G6PD, respectively. The presence and formation of the enzymes was investigated in those individuals that had not received the corresponding genes from the mother. We revealed maternal forms of the enzymes, detectable up to the pupal stage. The activities of “maternal” 6PGD and G6PD per individual increased 20‐fold to 30‐fold from the egg stage to the 3rd larval instar even in the absence of normal Pgd and Zw genes. Immunologic studies have shown that the increase in 6PGD activity is due to an accumulation of the maternal form of the enzyme molecules. We revealed a hybrid isozyme resulting from an aggregation of the subunits of isozymes controlled by the genes of the mother and embryo itself. These results indicate that the maternal effect in the case of 6PGD is due to a long‐lived stable mRNA transmitted with the egg cytoplasm and translated during the development of Drosophila melanogaster.

Journal

Genesis: the Journal of Genetics and DevelopmentWiley

Published: Jan 1, 1979

Keywords: ; ; ;

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