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/lp/wiley/mapping-of-a-gene-for-nonspecific-x-linked-mental-retardation-mrx-75-TYOS2f20a5
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- Publisher
- Wiley
- Copyright
- Copyright © 2000 Wiley‐Liss, Inc.
- ISSN
- 1552-4868
- eISSN
- 1552-4833
- DOI
- 10.1002/1096-8628(20000814)93:4<290::AID-AJMG7>3.3.CO;2-D
- Publisher site
- See Article on Publisher Site
Abstract
Nonspecific X‐linked mental retardation is a heterogeneous condition consisting of non‐syndromal mental retardation in males. It is caused by mutation in one of several genes on the X chromosome (MRX genes). Here we report on the localization of a presumptive MRX gene to chromosomal region Xq24–q26 in a German family with nonspecific X‐linked mental retardation (MRX 75, HUGO Human Gene Nomenclature Committee). Two point linkage analysis with 23 informative markers gave a lod score of 2.53 at Θ = 0 for markers DXS425, DXS1254, DXS1114, and HPRT. Am. J. Med. Genet. 93:290–293, 2000. © 2000 Wiley‐Liss, Inc.
Journal
American Journal of Medical Genetics – Wiley
Published: Aug 14, 2000
Keywords: X‐linked mental retardation; nonspecific mental retardation; MRX genes; Xq24–q26