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LETTER TO THE EDITORS

LETTER TO THE EDITORS LETTER TO T H E EDITORS :s Unusual Deletions in the Immunoglobulin Heavy Chain Locus in Follicular 6-Cell Lymphoma With t( 14; I8)(q32.3;q2 I .3) A recent paper in Genes, Chromosomes @ Cancer described the detection by pulsed-field gel electrophoresis of unexpected and peculiar deletions in the immunoglobulin heavy chain locus (ZGH) in the derivative chromosome 14 in at least 76% of follicular B-cell non-Hodgkin lymphomas (B-NHL) with t(14; 18)(q32.3;q21.3) (Zelenetz et al., 1993). These deletions were compared with the deletions of the immunoglobulin constant region genes (C,) associated with normal class-switching and it was suggested that the deletions may have arisen as a consequence of “non-physiologic activation of the recombinases involved in class-switching.” Whilst some of the deletions reported may indeed represent the effects of deletional ZGH classswitching, the majority do not. Furthermore, from analysis of the presented data it is possible to deduce preliminary evidence for an unusual type of ZGH deletion of about 200 kb in the majority of these derivative chromosomes with a breakpoint immediately of 5’ of C p but outside S k . There are a number of features concerning the nature of both follicular B-NHL and of the deletions themselves which http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Genes, Chromosomes and Cancer Wiley

LETTER TO THE EDITORS

Dyer, M J S
Genes, Chromosomes and Cancer , Volume 8 (4) – Dec 1, 1993
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Publisher
Wiley
Copyright
Copyright © 1993 Wiley‐Liss, Inc., A Wiley Company
ISSN
1045-2257
eISSN
1098-2264
DOI
10.1002/gcc.2870080410
Publisher site
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Abstract

LETTER TO T H E EDITORS :s Unusual Deletions in the Immunoglobulin Heavy Chain Locus in Follicular 6-Cell Lymphoma With t( 14; I8)(q32.3;q2 I .3) A recent paper in Genes, Chromosomes @ Cancer described the detection by pulsed-field gel electrophoresis of unexpected and peculiar deletions in the immunoglobulin heavy chain locus (ZGH) in the derivative chromosome 14 in at least 76% of follicular B-cell non-Hodgkin lymphomas (B-NHL) with t(14; 18)(q32.3;q21.3) (Zelenetz et al., 1993). These deletions were compared with the deletions of the immunoglobulin constant region genes (C,) associated with normal class-switching and it was suggested that the deletions may have arisen as a consequence of “non-physiologic activation of the recombinases involved in class-switching.” Whilst some of the deletions reported may indeed represent the effects of deletional ZGH classswitching, the majority do not. Furthermore, from analysis of the presented data it is possible to deduce preliminary evidence for an unusual type of ZGH deletion of about 200 kb in the majority of these derivative chromosomes with a breakpoint immediately of 5’ of C p but outside S k . There are a number of features concerning the nature of both follicular B-NHL and of the deletions themselves which

Journal

Genes, Chromosomes and Cancer – Wiley

Published: Dec 1, 1993

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