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Laying the groundwork for growth: Cell–cell and cell–ECM interactions in cardiovascular development

Laying the groundwork for growth: Cell–cell and cell–ECM interactions in cardiovascular development Cardiac development is reliant upon the spatial and temporal regulation of both genetic and chemical signals. Central to the communication of these signals are direct interactions between cells and their surrounding environment. The extracellular matrix (ECM) plays an integral role in cell communication and tissue growth throughout development by providing both structural support and chemical signaling factors. The present review discusses elements of cell–cell and cell–ECM interactions involved in cardiogenesis, and how disruption of these interactions can result in numerous heart defects. Examining the relationships between cells and their immediate environment has implications for novel and existing therapeutic strategies to combating congenital disorders. Birth Defects Research (Part C) 90:1–7, 2010. © 2010 Wiley‐Liss, Inc. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Birth Defects Research Part C Wiley

Laying the groundwork for growth: Cell–cell and cell–ECM interactions in cardiovascular development

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References (67)

Publisher
Wiley
Copyright
Copyright © 2010 Wiley‐Liss, Inc., A Wiley Company
ISSN
1542-975X
eISSN
1542-9768
DOI
10.1002/bdrc.20168
pmid
20301223
Publisher site
See Article on Publisher Site

Abstract

Cardiac development is reliant upon the spatial and temporal regulation of both genetic and chemical signals. Central to the communication of these signals are direct interactions between cells and their surrounding environment. The extracellular matrix (ECM) plays an integral role in cell communication and tissue growth throughout development by providing both structural support and chemical signaling factors. The present review discusses elements of cell–cell and cell–ECM interactions involved in cardiogenesis, and how disruption of these interactions can result in numerous heart defects. Examining the relationships between cells and their immediate environment has implications for novel and existing therapeutic strategies to combating congenital disorders. Birth Defects Research (Part C) 90:1–7, 2010. © 2010 Wiley‐Liss, Inc.

Journal

Birth Defects Research Part CWiley

Published: Mar 1, 2010

Keywords: cardiac development; vascular development; extracellular matrix; cell–cell interactions; cell–ECM interactions; congenital heart defects

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