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Is There An Answer? is intended to serve as a forum in which readers to IUBMB Life may pose questions of the type that intrigue biochemists but for which there may be no obvious answer or one may be available but not widely known or easily accessible. Readers are invited to e-mail f.vella@sasktel.net if they have questions to contribute or if they can provide answers to questions that are provided here from time to time. In the latter case, instructions will be sent to interested readers. Answers should be, whenever possible, evidencebased and provide relevant references. âFrank Vella Q&A Question: Are patients taking statins, which are HMG-CoA reductase inhibitors, to reduce their cholesterol, in danger of being deï¬cient in coenzyme Q? Answer: E J Wood, School of Biochemistry & Microbiology, University of Leeds, Leeds LS2 9JT, UK. E-mail: e.j.wood@Leeds.ac.uk All the isoprenoid derivatives are synthesized by a common pathway through HMG-CoA reductase (Fig. 1). Cholesterol and other sterols are made by this route, but of course cholesterol is also obtained from the diet. Statins are drugs that are widely used for treating hypercholesterolemia and numerous epidemiological studies have demonstrated their eï¬cacy in reducing total plasma cholesterol and the
IUBMB Life – Wiley
Published: Jul 1, 2004
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