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- Publisher
- Wiley
- Copyright
- Copyright © 1997 Wiley‐Liss, Inc.
- ISSN
- 0741-0395
- eISSN
- 1098-2272
- DOI
- 10.1002/(SICI)1098-2272(1997)14:6<635::AID-GEPI14>3.3.CO;2-R
- Publisher site
- See Article on Publisher Site
Abstract
Assessing heterogeneity in affected relative pair linkage analysis can help control type I error or identify important subgroups. We develop a method to incorporate covariates into sib‐pair analysis, and hence are able to test for covariate effects on allele sharing in sib pairs. We propose a way of combining the five bipolar data sets to do a joint analysis of chromosome 18 data using this new method. Our results from a limited set of analyses do not show significant heterogeneity, and do not confirm the linkage previously identified on chromosome 18. © 1997 Wiley‐Liss, Inc.
Journal
Genetic Epidemiology – Wiley
Published: Jan 1, 1997
Keywords: allele sharing; heterogeneity; imprinting; linkage; parent of origin; regression