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In vitro and in vivo kinetics of regulated drug release from polymer matrices by oscillating magnetic fields

In vitro and in vivo kinetics of regulated drug release from polymer matrices by oscillating... The kinetics of drug release from polymerdrug matrices containing an embedded magnet was continuously monitored in vitro and in vivo. The application of an oscillating magnetic field increased the rate of drug release from the polymer matrices. Within the limits of detection the increase in release occurred immediately, remained stable for as long as the field was applied, and returned exactly to baseline upon withdrawal of the field. The increase in release was directly proportional to field amplitude. The same pattern of results were observed in vivo as in vitro, though higher strength fields were required in vivo to achieve the same effect observed in vitro. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Biomedical Materials Research Part A Wiley

In vitro and in vivo kinetics of regulated drug release from polymer matrices by oscillating magnetic fields

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References (9)

Publisher
Wiley
Copyright
Copyright © 1987 Wiley Subscription Services, Inc., A Wiley Company
ISSN
1549-3296
eISSN
1552-4965
DOI
10.1002/jbm.820210307
pmid
3558448
Publisher site
See Article on Publisher Site

Abstract

The kinetics of drug release from polymerdrug matrices containing an embedded magnet was continuously monitored in vitro and in vivo. The application of an oscillating magnetic field increased the rate of drug release from the polymer matrices. Within the limits of detection the increase in release occurred immediately, remained stable for as long as the field was applied, and returned exactly to baseline upon withdrawal of the field. The increase in release was directly proportional to field amplitude. The same pattern of results were observed in vivo as in vitro, though higher strength fields were required in vivo to achieve the same effect observed in vitro.

Journal

Journal of Biomedical Materials Research Part AWiley

Published: Mar 1, 1987

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