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HLA class II typing using oligonucleotide probes

HLA class II typing using oligonucleotide probes A DQβ locus‐specific oligonucleotide probe is used to identify DQβ alleles present in six insulin‐dependent diabetes mellitus (IDDM) multiplex families. Results of genotyping using this technique agree with those from cDNA probes and are often clearer. Allele‐specific oligonucleotide probes for the DRβ locus are used to identify subtypes (Dw4 and Dw14) of the DR4 specificity in five IDDM multiplex families. This distinction cannot be made with available cDNA probes. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Genetic Epidemiology Wiley

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References (10)

Publisher
Wiley
Copyright
Copyright © 1989 Wiley‐Liss, Inc., A Wiley Company
ISSN
0741-0395
eISSN
1098-2272
DOI
10.1002/gepi.1370060107
pmid
2499503
Publisher site
See Article on Publisher Site

Abstract

A DQβ locus‐specific oligonucleotide probe is used to identify DQβ alleles present in six insulin‐dependent diabetes mellitus (IDDM) multiplex families. Results of genotyping using this technique agree with those from cDNA probes and are often clearer. Allele‐specific oligonucleotide probes for the DRβ locus are used to identify subtypes (Dw4 and Dw14) of the DR4 specificity in five IDDM multiplex families. This distinction cannot be made with available cDNA probes.

Journal

Genetic EpidemiologyWiley

Published: Jan 1, 1989

Keywords: HLA class II alleles; HLA‐DR4 subtypes; HLA DQβ genotypes; IDDM; RFLP analysis; molecular genotyping techniques; Dw4‐83 oligonucleotide; Dw14‐68 oligonucleotide; DQβ‐5 oligonucleotide; locus‐specific probes; allele‐specific probes

There are no references for this article.