Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

GM‐CSF induces the tyrosine phosphorylation of three isoforms of shc and its association with GRB2 in TF‐1 cell

GM‐CSF induces the tyrosine phosphorylation of three isoforms of shc and its association with... 10.1080/15216549600201232.abs This report demonstrates that GM‐CSF induces the tyrosine phosphorylation of Shc protein which is implicated in Ras activation. Three isoforms of She are ubiqitously phosphorylated induced by GM‐CSF in TF‐1, a cell line of erythroid origin. It is also shown that She is associated with the adaptor protein Grb2. The formation of Shc‐Grb2 complex may directly link tyrosine phosphorylation events to Ras activation in TF‐1 cells. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png IUBMB Life Wiley

GM‐CSF induces the tyrosine phosphorylation of three isoforms of shc and its association with GRB2 in TF‐1 cell

Shi, Xiaoqing; Qin, Junchuan; Zhu, Dexu
IUBMB Life , Volume 39 (5) – Aug 1, 1996
Download PDF
6 pages

Loading next page...
 
/lp/wiley/gm-csf-induces-the-tyrosine-phosphorylation-of-three-isoforms-of-shc-5oJwizBNZB

References (0)

References for this paper are not available at this time. We will be adding them shortly, thank you for your patience.

Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
Copyright © 1996 International Union of Biochemistry and Molecular Biology
ISSN
1521-6543
eISSN
1521-6551
DOI
10.1080/15216549600201232
Publisher site
See Article on Publisher Site

Abstract

10.1080/15216549600201232.abs This report demonstrates that GM‐CSF induces the tyrosine phosphorylation of Shc protein which is implicated in Ras activation. Three isoforms of She are ubiqitously phosphorylated induced by GM‐CSF in TF‐1, a cell line of erythroid origin. It is also shown that She is associated with the adaptor protein Grb2. The formation of Shc‐Grb2 complex may directly link tyrosine phosphorylation events to Ras activation in TF‐1 cells.

Journal

IUBMB Life – Wiley

Published: Aug 1, 1996

There are no references for this article.