Access the full text.
Sign up today, get DeepDyve free for 14 days.
R. Rugh (1968)
The mouse; its reproduction and development
E. Eicher, L. Washburn (1986)
Genetic control of primary sex determination in mice.Annual review of genetics, 20
Robert Edwards (1970)
Are oocytes formed and used sequentially in the mammalian ovary?Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 259 828
A. Byskov (1975)
The role of the rete ovarii in meiosis and follicle formation in the cat, mink and ferret.Journal of reproduction and fertility, 45 2
Anne Byskov, Niels SKAKKEBAiKt, Gerd STAFANGERt, H. Peters (1977)
Influence of ovarian surface epithelium and rete ovarii on follicle formation.Journal of anatomy, 123 Pt 1
K. McClellan, R. Gosden, T. Taketo (2003)
Continuous loss of oocytes throughout meiotic prophase in the normal mouse ovary.Developmental biology, 258 2
H. Schöler, S. Ruppert, N. Suzuki, K. Chowdhury, P. Gruss (1990)
New type of POU domain in germ line-specific protein Oct-4Nature, 344
A. McLaren (1984)
Meiosis and differentiation of mouse germ cells.Symposia of the Society for Experimental Biology, 38
Alexander Brehm, C. Ovitt, H. Schöler (1998)
Oct‐4: more than just a POUerful marker of the mammalian germline?APMIS, 106
Y. Ohkubo, Y. Shirayoshi, N. Nakatsuji (1996)
Autonomous regulation of proliferation and growth arrest in mouse primordial germ cells studied by mixed and clonal cultures.Experimental cell research, 222 2
H. Schöler, G. Dressler, R. Balling, H. Rohdewohld, Peter Gruss (1990)
Oct‐4: a germline‐specific transcription factor mapping to the mouse t‐complex.The EMBO Journal, 9
S. Meredith, D. Doolin (1997)
Timing of activation of primordial follicles in mature rats is only slightly affected by fetal stage at meiotic arrest.Biology of reproduction, 57 1
H. Peters (1970)
Migration of gonocytes into the mammalian gonad and their differentiation.Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 259 828
D. Menke, D. Page (2002)
Sexually dimorphic gene expression in the developing mouse gonad.Gene expression patterns : GEP, 2 3-4
J. Christiansen, C. Dennis, C. Wicking, S. Monkley, D. Wilkinson, B. Wainwright (1995)
Murine Wnt-11 and Wnt-12 have temporally and spatially restricted expression patterns during embryonic developmentMechanisms of Development, 51
A. Byskov (1978)
Regulation of Initiation of Meiosis in Fetal GonadsInternational Journal of Andrology, 1
N. Nakatsuji, S. Chuma (2001)
Differentiation of mouse primordial germ cells into female or male germ cells.The International journal of developmental biology, 45 3
(1988)
The mammalian ovum
Michael Bendel-Stenzel, Robert Anderson, J. Heasman, C. Wylie (1998)
The origin and migration of primordial germ cells in the mouse.Seminars in cell & developmental biology, 9 4
A. Hacker, B. Capel, P. Goodfellow, R. Lovell-Badge (1995)
Expression of Sry, the mouse sex determining gene.Development, 121 6
L. Zamboni, Shakti Upadhyay (1983)
Germ cell differentiation in mouse adrenal glands.The Journal of experimental zoology, 228 2
P. Polani, J. Crolla (1991)
A test of the production line hypothesis of mammalian oogenesisHuman Genetics, 88
S. Henderson, R. Edwards (1968)
Chiasma Frequency and Maternal Age in MammalsNature, 218
A. Jost, J. Prepin, B. Vigier (1977)
Hormones in the morphogenesis of the genital system.Birth defects original article series, 13 2
M. Pesce, Xiangyuan Wang, D. Wolgemuth, H. Schöler (1998)
Differential expression of the Oct-4 transcription factor during mouse germ cell differentiationMechanisms of Development, 71
P. Koopman, J. Gubbay, N. Vivian, P. Goodfellow, R. Lovell-Badge (1991)
Male development of chromosomally female mice transgenic for SryNature, 351
M. Bullejos, P. Koopman (2001)
Spatially dynamic expression of Sry in mouse genital ridgesDevelopmental Dynamics, 221
A. McLaren (1995)
Germ cells and germ cell sex.Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 350 1333
A. McLaren (1981)
The fate of germ cells in the testis of fetal Sex-reversed mice.Journal of reproduction and fertility, 61 2
M. Dobson, R. Pearlman, A. Karaiskakis, B. Spyropoulos, P. Moens (1994)
Synaptonemal complex proteins: occurrence, epitope mapping and chromosome disjunction.Journal of cell science, 107 ( Pt 10)
(1981)
Growth and differentiation of foetal mouse gonads in culture studied by flow cytometry on nuclear suspensions
S. Dolci, M. Felici (1990)
A study of meiosis in chimeric mouse fetal gonads.Development, 109 1
C. Nagamine, T. Taketo, G. Koo (1987)
Morphological development of the mouse gonad in tda-1 XY sex reversal.Differentiation; research in biological diversity, 33 3
A. McLaren (2000)
Germ and somatic cell lineages in the developing gonadMolecular and Cellular Endocrinology, 163
Anne Byskov, Lauri Saxén (1976)
Induction of meiosis in fetal mouse testis in vitro.Developmental biology, 52 2
R. Saunders (2000)
In situ hybridization to polytene chromosomes.Methods in molecular biology, 123
C. Nagamine, J. Capehart, C. Carlisle, Dennis Chang (1998)
Ovotestes in B6-XXSxr sex-reversed mice.Developmental biology, 196 1
D. Wilkinson, M. Nieto (1993)
Detection of messenger RNA by in situ hybridization to tissue sections and whole mounts.Methods in enzymology, 225
H. Yao, B. Capel (2002)
Disruption of testis cords by cyclopamine or forskolin reveals independent cellular pathways in testis organogenesis.Developmental biology, 246 2
R. Behringer, M. Finegold, R. Cate (1994)
Müllerian-inhibiting substance function during mammalian sexual developmentCell, 79
Kathleen Molyneaux, J. Stallock, K. Schaible, C. Wylie (2001)
Time-lapse analysis of living mouse germ cell migration.Developmental biology, 240 2
Sandro Francavilla, Sandro Francavilla, Luciano Zamboni, Luciano Zamboni (1985)
Differentiation of mouse ectopic germinal cells in intra- and perigonadal locations.The Journal of experimental zoology, 233 1
D. Menke, J. Koubová, D. Page (2003)
Sexual differentiation of germ cells in XX mouse gonads occurs in an anterior-to-posterior wave.Developmental biology, 262 2
M. Gomperts, Chris Wylie, J. Heasman (2004)
Primordial germ cell migration.Developmental biology, 2
A. Byskov (1974)
Does the rete ovarii act as a trigger for the onset of meiosis?Nature, 252
C. Tease, G. Fisher (2004)
Further examination of the production-line hypothesis in mouse foetal oocytesChromosoma, 97
Anne Byskov, Claus Andersen, L. Nordholm, H. Thøgersen, Guoliang Xia, O. Wassmann, Jan Andersen, E. Guddal, T. Roed (1995)
Chemical structure of sterols that activate oocyte meiosisNature, 374
B. Mintz, E. Russell (1957)
Gene-induced embryological modifications of primordial germ cells in the mouse.The Journal of experimental zoology, 134 2
M. Gomperts, M. García-Castro, C. Wylie, J. Heasman (1994)
Interactions between primordial germ cells play a role in their migration in mouse embryos.Development, 120 1
A. McLaren (1980)
Oocytes in the testisNature, 283
A. Byskov, J. Grinsted (1981)
Feminizing effect of mesonephros on cultured differentiating mouse gonads and ducts.Science, 212 4496
Murray Hargrave, J. Bowles, P. Koopman (2000)
In situ hybridization of whole-mount embryos.Methods in molecular biology, 123
A. Byskov, M. Baltsen, C. Andersen (1998)
Meiosis-activating sterols: background, discovery, and possible useJournal of Molecular Medicine, 76
J. Lammers, H. Offenberg, M. Aalderen, A. Vink, A. Dietrich, C. Heyting (1994)
The gene encoding a major component of the lateral elements of synaptonemal complexes of the rat is related to X-linked lymphocyte-regulated genesMolecular and Cellular Biology, 14
M. Rosner, M. Vigano, K. Ozato, P. Timmons, Francoise Poirie, P. Rigby, L. Staudt (1990)
A POU-domain transcription factor in early stem cells and germ cells of the mammalian embryoNature, 345
A. Byskov (1979)
Regulation of meiosis in mammalsAnnales De Biologie Animale Biochimie Biophysique, 19
S. Palmer, P. Burgoyne (1991)
In situ analysis of fetal, prepuberal and adult XX----XY chimaeric mouse testes: Sertoli cells are predominantly, but not exclusively, XY.Development, 112 1
U. Drews (2001)
Local mechanisms in sex specific morphogenesisCytogenetic and Genome Research, 91
A. Carlo, Gabriele Travia, M. Felici (2000)
The meiotic specific synaptonemal complex protein SCP3 is expressed by female and male primordial germ cells of the mouse embryo.The International journal of developmental biology, 44 2
A. Byskov, M. Fenger, L. Westergaard, C. Andersen (1993)
Forskolin and the meiosis inducing substance synergistically initiate meiosis in fetal male germ cellsMolecular Reproduction and Development, 34
Chris Wylie (2000)
Germ cells.Current opinion in genetics & development, 10 4
Dr. Theiler (1989)
The House Mouse
A. Hadjantonakis, M. Gertsenstein, M. Ikawa, M. Okabe, A. Nagy (1998)
Non-invasive sexing of preimplantation stage mammalian embryosNature Genetics, 19
I. Adams, A. McLaren (2002)
Sexually dimorphic development of mouse primordial germ cells: switching from oogenesis to spermatogenesis.Development, 129 5
Michael Bendel-Stenzel, M. Gomperts, Robert Anderson, J. Heasman, C. Wylie (2000)
The role of cadherins during primordial germ cell migration and early gonad formation in the mouseMechanisms of Development, 91
A. McLaren, D. Southee (1997)
Entry of mouse embryonic germ cells into meiosis.Developmental biology, 187 1
Anne Byskov (1978)
The anatomy and ultrastructure of the rete system in the fetal mouse ovary.Biology of reproduction, 19 4
R. Speed, A. Chandley (1983)
Meiosis in the foetal mouse ovaryChromosoma, 88
Y. Yeom, G. Fuhrmann, C. Ovitt, A. Brehm, K. Ohbo, M. Gross, K. Hübner, H. Schöler (1996)
Germline regulatory element of Oct-4 specific for the totipotent cycle of embryonal cells.Development, 122 3
Germ cells in the mouse embryo remain undifferentiated until about 13.5 days post‐coitum (dpc), when male germ cells enter mitotic arrest and female germ cells enter meiosis. The molecular signals and transcriptional control mechanisms governing the differential fate of germ cells in males and females remain largely unknown. In order to gain insights into the behavior of germ cells around this period and into likely mechanisms controlling entry into meiosis, we have studied by wholemount in situ hybridization the expression pattern of two germ cell‐specific markers, Oct4 and Sycp3, during mouse fetal gonad development. We observed a dynamic wave of expression of both genes in developing ovaries, with Oct4 expression being extinguished in a rostro‐caudal wave and Sycp3 being upregulated in a corresponding wave, during the period 13.5–15.5 dpc. These results indicate that entry into meiosis proceeds in a rostro‐caudal progression, in turn suggesting that somatically derived signals may contribute to the control of germ cell entry into meiosis in developing ovaries. Mol. Reprod. Dev. 68: 422–428, 2004. © 2004 Wiley‐Liss, Inc.
Molecular Reproduction & Development – Wiley
Published: Aug 1, 2004
Keywords: ovary; germ cells; meiosis; Sycp3 ; Oct4 ; in situ hybridization
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.