Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Genetic screen for small body size mutants in C. elegans reveals many TGFβ pathway components

Genetic screen for small body size mutants in C. elegans reveals many TGFβ pathway components In the nematode Caenorhabditis elegans, a TGFβ‐related signaling pathway regulates body size and male tail morphogenesis. We sought to identify genes encoding components or modifiers of this pathway in a large‐scale genetic screen. Remarkably, this screen was able to identify essentially all core components of the TGFβ signaling pathway. Among 34 Small mutants, many mutations disrupt genes encoding recognizable components of the TGFβ pathway: DBL‐1 ligand, DAF‐4 type II receptor, SMA‐6 type I receptor, and SMA‐2, SMA‐3, and SMA‐4 Smads. Moreover, we find that at least 11 additional complementation groups can mutate to the Small phenotype. Four of these 11 genes, sma‐9, sma‐14, sma‐16, and sma‐20 affect male tail morphogenesis as well as body size. Two genes, sma‐11 and sma‐20, also influence regulation of the developmentally arrested dauer larval stage, suggesting a role in a second characterized TGFβ pathway in C. elegans. Other genes may represent tissue‐specific factors or parallel pathways for body size control. Because of the conservation of TGFβ signaling pathways, homologs of these genes may be involved in tissue specificity and/or crosstalk of TGFβ pathways in other animals. genesis 35:239–247, 2003. © 2003 Wiley‐Liss, Inc. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Genesis: the Journal of Genetics and Development Wiley

Genetic screen for small body size mutants in C. elegans reveals many TGFβ pathway components

Loading next page...
 
/lp/wiley/genetic-screen-for-small-body-size-mutants-in-c-elegans-reveals-many-Ux2A0U0T9H

References (40)

Publisher
Wiley
Copyright
Copyright © 2003 Wiley Subscription Services, Inc., A Wiley Company
ISSN
1526-954X
eISSN
1526-968X
DOI
10.1002/gene.10184
pmid
12717735
Publisher site
See Article on Publisher Site

Abstract

In the nematode Caenorhabditis elegans, a TGFβ‐related signaling pathway regulates body size and male tail morphogenesis. We sought to identify genes encoding components or modifiers of this pathway in a large‐scale genetic screen. Remarkably, this screen was able to identify essentially all core components of the TGFβ signaling pathway. Among 34 Small mutants, many mutations disrupt genes encoding recognizable components of the TGFβ pathway: DBL‐1 ligand, DAF‐4 type II receptor, SMA‐6 type I receptor, and SMA‐2, SMA‐3, and SMA‐4 Smads. Moreover, we find that at least 11 additional complementation groups can mutate to the Small phenotype. Four of these 11 genes, sma‐9, sma‐14, sma‐16, and sma‐20 affect male tail morphogenesis as well as body size. Two genes, sma‐11 and sma‐20, also influence regulation of the developmentally arrested dauer larval stage, suggesting a role in a second characterized TGFβ pathway in C. elegans. Other genes may represent tissue‐specific factors or parallel pathways for body size control. Because of the conservation of TGFβ signaling pathways, homologs of these genes may be involved in tissue specificity and/or crosstalk of TGFβ pathways in other animals. genesis 35:239–247, 2003. © 2003 Wiley‐Liss, Inc.

Journal

Genesis: the Journal of Genetics and DevelopmentWiley

Published: Apr 1, 2003

Keywords: ; ; ; ;

There are no references for this article.